{"id":"W3097838507","doi":"10.1182/blood-2020-141925","title":"Tonic Signaling Leads to Off-Target Activation of T Cells Engineered with Chimeric Antigen Receptors That Is Not Seen in T Cells Engineered with T Cell Antigen Coupler (TAC) Receptors","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"T-cell receptor; Chimeric antigen receptor; Cell biology; T cell; Antigen; Cytotoxic T cell; Receptor; Antigen-presenting cell; Molecular biology; Biology; Chemistry; Immunology; Immune system; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001608331,0.000378214,0.0002577394,0.0001876413,0.00008826319,0.0004391067,0.0002030824,0.0003882138,0.0009348753],"category_scores_gemma":[0.0001833949,0.0001872206,0.0002443339,0.0001240734,0.0001759048,0.0002297857,0.0002592806,0.0007051303,0.0005187896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001937722,"about_ca_system_score_gemma":0.000127496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002510357,"about_ca_topic_score_gemma":0.0003018533,"domain_scores_codex":[0.9997126,0.00003692677,0.00002349185,0.00004949209,0.00007710841,0.0001003834],"domain_scores_gemma":[0.9998335,0.00003404611,0.00004485403,0.00002404277,0.00001998519,0.00004361313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003059617,0.0000149892,0.00006088107,0.00001022874,0.000002322028,0.00003364237,0.000007130895,0.00005872966,0.9990797,0.0001194192,0.00002820845,0.0005541622],"study_design_scores_gemma":[0.00002060833,0.0003432403,0.001216679,0.000005288353,0.00002103482,0.0004683562,0.00001402103,0.002151961,0.993405,0.00007603018,0.00227321,0.00000455589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903089,0.0005228955,0.00628636,0.00005930357,0.0000331087,0.00002358267,0.0001022721,0.0001453114,0.002518319],"genre_scores_gemma":[0.9958435,0.0002391443,0.001519259,0.00007440646,0.00000923766,0.00001884472,0.0002014156,0.00003873129,0.002055545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009348753,"threshold_uncertainty_score":0.003127456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02032363054291216,"score_gpt":0.2408084005636281,"score_spread":0.2204847700207159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}