{"id":"W3097869998","doi":"10.1128/aac.01592-20","title":"Structural and Cellular Insights into the <scp>l</scp> , <scp>d</scp> -Transpeptidase YcbB as a Therapeutic Target in Citrobacter rodentium, <i>Salmonella</i> Typhimurium, and <i>Salmonella</i> Typhi Infections","year":2020,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Microbiology; Shigella; Salmonella; Context (archaeology); Salmonella typhi; Citrobacter; Citrobacter rodentium; Enterobacteriaceae; Cell wall; Biology; Bacterial cell structure; Bacterial outer membrane; Bacteria; Typhoid fever; Escherichia coli; Pathogen; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007504484,0.0001874713,0.00007967111,0.0001077124,0.0001365074,0.0002488557,0.0001478084,0.0003280803,0.0009793292],"category_scores_gemma":[0.00005437226,0.0001119094,0.0001241049,0.00009727705,0.0003186773,0.0002593971,0.0001330033,0.0004517387,0.0002443097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002764366,"about_ca_system_score_gemma":0.0002461977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000669799,"about_ca_topic_score_gemma":0.0008876895,"domain_scores_codex":[0.9999771,0.000004042775,0.000001243264,0.000003538318,0.000005426335,0.000008610361],"domain_scores_gemma":[0.9999661,0.000005445456,0.00001040371,0.000003498255,0.0000039937,0.00001048625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008862481,0.00001421929,0.0001501293,0.00006178524,0.00000230415,0.0001319076,0.00002742564,0.0003266601,0.996146,0.001023042,0.00005380029,0.001974241],"study_design_scores_gemma":[0.00001445653,0.0003697572,0.005473308,0.00002967935,0.00001891207,0.0008137526,0.0002683901,0.002772776,0.9744079,0.001006614,0.01481619,0.000008435976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786375,0.007930977,0.006345021,0.0008547675,0.0000366114,0.0000113926,0.0001727219,0.00005893212,0.005952143],"genre_scores_gemma":[0.9934533,0.002464943,0.0027375,0.00009779559,0.0000057402,0.000003839448,0.0001319863,0.000005570383,0.001099381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009793292,"threshold_uncertainty_score":0.003276169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009088817851518476,"score_gpt":0.2108957167777882,"score_spread":0.2018068989262697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}