{"id":"W3097869998","doi":"10.1128/aac.01592-20","title":"Structural and Cellular Insights into the <scp>l</scp> , <scp>d</scp> -Transpeptidase YcbB as a Therapeutic Target in Citrobacter rodentium, <i>Salmonella</i> Typhimurium, and <i>Salmonella</i> Typhi Infections","year":2020,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Microbiology; Shigella; Salmonella; Context (archaeology); Salmonella typhi; Citrobacter; Citrobacter rodentium; Enterobacteriaceae; Cell wall; Biology; Bacterial cell structure; Bacterial outer membrane; Bacteria; Typhoid fever; Escherichia coli; Pathogen; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001617282,0.0004918978,0.0004609565,0.0001051433,0.0004885999,0.0003861015,0.0002517891,0.0002501583,0.00008648013],"category_scores_gemma":[0.00003691155,0.0003622708,0.0001010848,0.0003716123,0.0003738837,0.0003928016,0.0001042396,0.0003792264,0.00003507115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002567196,"about_ca_system_score_gemma":0.00004244237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002696326,"about_ca_topic_score_gemma":0.00009862402,"domain_scores_codex":[0.9978625,0.0001472546,0.0004426752,0.0007927768,0.000234978,0.0005198832],"domain_scores_gemma":[0.9990543,0.0001837604,0.0001774232,0.0002858898,0.00006909662,0.0002294922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000446946,0.00007818773,0.01552347,0.0001228905,0.00008847679,0.00002753216,0.01830402,0.00008001548,0.9573864,0.0001492472,0.007767355,0.0004276666],"study_design_scores_gemma":[0.005127761,0.0006621076,0.03864176,0.0001229507,0.0002000166,0.0001363638,0.001925278,0.000763383,0.7979992,0.003722821,0.1502696,0.0004287883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958305,0.0010457,0.0001929613,0.001079374,0.0004239207,0.0005139887,0.00002156481,0.00009784544,0.0007940987],"genre_scores_gemma":[0.9857333,0.001867778,0.0001782415,0.01131563,0.0003731607,0.00001290128,0.00003863663,0.0000670616,0.0004132798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1593873,"threshold_uncertainty_score":0.9998829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009088817851518476,"score_gpt":0.2108957167777882,"score_spread":0.2018068989262697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}