{"id":"W3097912792","doi":"10.1182/blood-2020-136307","title":"CARTITUDE-1: Phase 1b/2 Study of Ciltacabtagene Autoleucel, a B-Cell Maturation Antigen-Directed Chimeric Antigen Receptor T Cell Therapy, in Relapsed/Refractory Multiple Myeloma","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Chimeric antigen receptor; Internal medicine; Antigen; Population; Fludarabine; Immunology; Oncology; Gastroenterology; Cyclophosphamide; Immunotherapy; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001335844,0.001270827,0.001072238,0.0004470464,0.0003219362,0.0007126949,0.0008603893,0.0009705034,0.004596485],"category_scores_gemma":[0.0004649446,0.0004578162,0.0007619598,0.0003337675,0.0005354934,0.0006925368,0.0003723453,0.002649665,0.0008191742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009316196,"about_ca_system_score_gemma":0.001550268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009737585,"about_ca_topic_score_gemma":0.002557097,"domain_scores_codex":[0.9997117,0.0001053117,0.00001498493,0.00005098727,0.00003558685,0.00008133055],"domain_scores_gemma":[0.9996414,0.00003431764,0.00005915334,0.0000256638,0.00002378331,0.0002156204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4582846,0.1658818,0.01614492,0.001529268,0.001179108,0.0007807437,0.0005166241,0.004569731,0.1637564,0.0005898328,0.01401985,0.1727471],"study_design_scores_gemma":[0.4872528,0.4680027,0.0208698,0.00005525837,0.0004983267,0.0006912895,0.00005536524,0.001701377,0.01298805,0.0002075297,0.007637122,0.00004038103],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897805,0.001735829,0.0005280724,0.0004640124,0.00008601641,0.002999446,0.002127803,0.0001887713,0.002089517],"genre_scores_gemma":[0.9803013,0.001636748,0.002325758,0.001241474,0.0001659828,0.0034383,0.006928037,0.00006844349,0.003894071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004596485,"threshold_uncertainty_score":0.01537675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0326984622809763,"score_gpt":0.2983293606355275,"score_spread":0.2656308983545512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}