{"id":"W3097912792","doi":"10.1182/blood-2020-136307","title":"CARTITUDE-1: Phase 1b/2 Study of Ciltacabtagene Autoleucel, a B-Cell Maturation Antigen-Directed Chimeric Antigen Receptor T Cell Therapy, in Relapsed/Refractory Multiple Myeloma","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Chimeric antigen receptor; Internal medicine; Antigen; Population; Fludarabine; Immunology; Oncology; Gastroenterology; Cyclophosphamide; Immunotherapy; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003649192,0.0003810839,0.000794951,0.0003139112,0.0000924948,0.00003389104,0.0003072278,0.0002072178,0.001413949],"category_scores_gemma":[0.0001316386,0.000356441,0.0001708262,0.00124665,0.00007790593,0.0001194898,0.00009658145,0.0006167015,0.00008967747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007290005,"about_ca_system_score_gemma":0.000257019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003424607,"about_ca_topic_score_gemma":0.00007163969,"domain_scores_codex":[0.99673,0.0003772661,0.0007875835,0.0007281649,0.0008394261,0.0005375297],"domain_scores_gemma":[0.998364,0.0001456937,0.0002775639,0.0006577326,0.0002299724,0.0003250119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003141465,0.02678425,0.04050491,0.0001309836,0.0002008415,0.0001542784,0.007837698,0.00001212876,0.9143112,2.069927e-7,0.0004403417,0.006481645],"study_design_scores_gemma":[0.07313462,0.009745675,0.06187971,0.00006115688,0.00008912748,0.000008947557,0.001308773,0.001080441,0.8480318,9.955986e-7,0.004269604,0.0003892159],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931629,0.002236297,0.00000888341,0.0001797646,0.0001375905,0.002706347,0.00003397964,0.0002391128,0.001295098],"genre_scores_gemma":[0.9969817,0.001120947,0.0004729451,0.0001637107,0.0002596361,0.00009587019,0.0001058246,0.0001068976,0.0006924091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06999315,"threshold_uncertainty_score":0.9998888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0326984622809763,"score_gpt":0.2983293606355275,"score_spread":0.2656308983545512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}