{"id":"W3097937986","doi":"10.1093/narcan/zcaa033","title":"APOBEC3 enzymes mediate efficacy of cisplatin and are epistatic with base excision repair and mismatch repair in platinum response","year":2020,"lang":"en","type":"article","venue":"NAR Cancer","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Cancer Institute; National Institutes of Health; Susan G. Komen for the Cure","keywords":"Cisplatin; Base excision repair; DNA mismatch repair; DNA repair; Uracil; Cancer research; Nucleotide excision repair; DNA damage; Chemistry; DNA; Biology; Genetics; Biochemistry; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003189958,0.000159579,0.0002425033,0.00004176431,0.00002988534,0.000005851499,0.00006747543,0.0001154817,0.00002409639],"category_scores_gemma":[0.0004154552,0.000137285,0.0000492794,0.0001279602,0.0000833592,0.000005852266,0.00008896872,0.00009469216,9.045015e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001697837,"about_ca_system_score_gemma":0.00009652448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005412741,"about_ca_topic_score_gemma":0.0001531209,"domain_scores_codex":[0.9988132,0.0001494675,0.000254499,0.0004465058,0.0001650043,0.0001713868],"domain_scores_gemma":[0.9993449,0.0000997403,0.000140157,0.0002415275,0.0000517815,0.0001218556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01129482,0.00009062509,0.03382663,0.0004102341,0.0001065482,0.0001460407,0.001893274,0.0001869217,0.9463561,0.00003023685,0.003565106,0.002093512],"study_design_scores_gemma":[0.007376834,0.002438442,0.09959953,0.0005460184,0.0001008617,0.00003966486,0.00106807,0.004994376,0.8756514,0.00007311631,0.007457979,0.000653752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961014,0.002780035,0.00007699551,0.0006170376,0.00002862913,0.000268144,0.00006414969,0.00003873783,0.0000248345],"genre_scores_gemma":[0.9952547,0.0002622294,0.003794746,0.00042377,0.00005088289,0.00003230152,0.00001281971,0.00002868029,0.0001398748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07070469,"threshold_uncertainty_score":0.5598321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01312277720308795,"score_gpt":0.2536446710945467,"score_spread":0.2405218938914588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}