{"id":"W3097937986","doi":"10.1093/narcan/zcaa033","title":"APOBEC3 enzymes mediate efficacy of cisplatin and are epistatic with base excision repair and mismatch repair in platinum response","year":2020,"lang":"en","type":"article","venue":"NAR Cancer","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Cancer Institute; National Institutes of Health; Susan G. Komen for the Cure","keywords":"Cisplatin; Base excision repair; DNA mismatch repair; DNA repair; Uracil; Cancer research; Nucleotide excision repair; DNA damage; Chemistry; DNA; Biology; Genetics; Biochemistry; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000175951,0.0002505568,0.0002006777,0.000325029,0.0002631563,0.0004257316,0.0002089715,0.0003776414,0.002888717],"category_scores_gemma":[0.0003495857,0.0001257044,0.000247039,0.000178747,0.0002124745,0.0002084818,0.0004752818,0.0005576105,0.0003003442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007311723,"about_ca_system_score_gemma":0.0004003994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003230987,"about_ca_topic_score_gemma":0.003929289,"domain_scores_codex":[0.9997386,0.00006421714,0.00001851607,0.00004487784,0.0000852181,0.00004855776],"domain_scores_gemma":[0.9997608,0.00004341414,0.00006910994,0.00001838916,0.00003350868,0.00007472438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001911238,0.00005289541,0.004599204,0.00003642476,0.00002349313,0.0002066338,0.00001882868,0.0002426846,0.9871926,0.0005786342,0.0002150569,0.006642383],"study_design_scores_gemma":[0.0000863486,0.0007782429,0.2614935,0.00002730462,0.000130089,0.003431924,0.0002415916,0.01085949,0.7076353,0.001488327,0.013773,0.0000547977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860517,0.002435405,0.005166836,0.0002832321,0.00004193909,0.00005761623,0.0004411436,0.0002156622,0.005306373],"genre_scores_gemma":[0.9971322,0.0002719084,0.0008030981,0.00005891461,0.000004071863,0.00001986458,0.00009705748,0.00001554157,0.001597396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003230987,"threshold_uncertainty_score":0.009663701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01312277720308795,"score_gpt":0.2536446710945467,"score_spread":0.2405218938914588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}