{"id":"W3097954755","doi":"10.1182/blood-2020-137215","title":"CRISPR Mediated <i>ELANE</i> Single-Allele Knock-out Restores Proliferation and Myeloid Differentiation of Neutropenia Patient Derived BM HSCs","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Biology; Myeloid; Population; Genetics; Allele; Cancer research; Medicine; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001930693,0.0002403161,0.0002489243,0.0001972589,0.0001474238,0.0002956133,0.0002398503,0.0003844013,0.003468419],"category_scores_gemma":[0.0001534525,0.0001300354,0.0002285707,0.00008644703,0.0002318778,0.0000960187,0.0002221622,0.0007936168,0.0008369436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001909881,"about_ca_system_score_gemma":0.0002146578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005231767,"about_ca_topic_score_gemma":0.001042121,"domain_scores_codex":[0.999799,0.00002129848,0.00002116746,0.00005096849,0.00007194972,0.00003563444],"domain_scores_gemma":[0.999925,0.00001765369,0.00001998721,0.00001031907,0.00000620144,0.00002081652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001284241,0.00003619339,0.0004356652,0.00007772907,0.00001432952,0.0003678938,0.00002932789,0.000267108,0.993161,0.0003147821,0.0007121215,0.004455458],"study_design_scores_gemma":[0.00008601136,0.0003338698,0.005577322,0.00002891854,0.00006085465,0.002522899,0.00004048196,0.00268642,0.9668232,0.0002036406,0.02161939,0.00001689897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.96122,0.001927462,0.01920205,0.000568071,0.0002124707,0.0001928991,0.003797935,0.002059332,0.01081978],"genre_scores_gemma":[0.9849057,0.0005709643,0.00617559,0.0003609967,0.00001633375,0.0001006202,0.001671283,0.0001165404,0.006082012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003468419,"threshold_uncertainty_score":0.01160306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0110389184255457,"score_gpt":0.2021656937174445,"score_spread":0.1911267752918988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}