{"id":"W3098014954","doi":"10.1101/2020.11.12.380675","title":"Developmental Single-cell transcriptomics in the <i>Lytechinus variegatus</i> Sea Urchin Embryo","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Planarian Biology and Electrostimulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Klarman Cell Observatory, Broad Institute; National Institutes of Health; National Science Foundation","keywords":"Lytechinus variegatus; Strongylocentrotus purpuratus; Sea urchin; Biology; Gastrulation; Embryo; Transcriptome; Gene regulatory network; Developmental biology; Gene; Evolutionary biology; Embryogenesis; Gene expression; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004922925,0.0004933887,0.0003590792,0.00009952786,0.0001545064,0.0001091119,0.0007610435,0.0008847803,0.000006859984],"category_scores_gemma":[0.0001238553,0.0004590841,0.0001415434,0.0002817747,0.000112601,0.000009059344,0.0002294295,0.00095444,0.0000247662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001057273,"about_ca_system_score_gemma":0.0005932593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003154501,"about_ca_topic_score_gemma":0.00002278655,"domain_scores_codex":[0.9976404,0.000276702,0.000446262,0.0009218513,0.0001971081,0.0005177207],"domain_scores_gemma":[0.9990523,0.00003468787,0.0002009995,0.0004999775,0.00008282439,0.0001292313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001558203,0.0001640308,0.003936176,0.00007926263,0.0000695953,0.0000420973,0.00002813289,0.0001259814,0.9929705,0.00008811236,0.002338502,0.000001842152],"study_design_scores_gemma":[0.001056226,0.0002220636,0.04609287,0.00006796364,0.00008578529,2.763802e-7,0.000006854763,0.0004215425,0.9239709,0.00001324951,0.027152,0.0009103065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916945,0.0009049368,0.004087371,0.001656018,0.0004244027,0.0007088445,0.0003383637,0.00008411403,0.0001014649],"genre_scores_gemma":[0.9936033,0.0001303939,0.001993113,0.003733727,0.000363272,0.00007920741,0.00002125879,0.00007040018,0.000005254336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06899959,"threshold_uncertainty_score":0.9997861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01273940377873462,"score_gpt":0.1973442203672387,"score_spread":0.1846048165885041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}