{"id":"W3098075819","doi":"10.3390/life10110295","title":"Genome Editing by CRISPR-Cas: A Game Change in the Genetic Manipulation of Chlamydomonas","year":2020,"lang":"en","type":"review","venue":"Life","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Mitacs; Canada Research Chairs","keywords":"CRISPR; Genome editing; Chlamydomonas reinhardtii; Transcription activator-like effector nuclease; Biology; Computational biology; Chlamydomonas; Zinc finger nuclease; Cas9; Genome; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005138066,0.0006674512,0.0008287773,0.001824719,0.0002466603,0.0008388986,0.0007193003,0.0008996118,0.001469758],"category_scores_gemma":[0.0004191388,0.0003290416,0.0005496895,0.001958671,0.0004326408,0.0009678644,0.0006130385,0.001647218,0.001000442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005268131,"about_ca_system_score_gemma":0.001034324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001291324,"about_ca_topic_score_gemma":0.001605083,"domain_scores_codex":[0.999796,0.00002211365,0.00002508667,0.0000437334,0.00009173504,0.00002144549],"domain_scores_gemma":[0.9998332,0.00007974062,0.00001988437,0.0000073294,0.0000389855,0.00002078979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006822133,0.00006675305,0.0001936344,0.0191039,0.0001131334,0.0003481221,0.00009572389,0.0006655311,0.01400756,0.005844588,0.01921569,0.9402772],"study_design_scores_gemma":[0.00001345526,0.00009650092,0.0008118556,0.001847479,0.0001309139,0.001300874,0.00004437669,0.0001584,0.003978648,0.001492049,0.9900973,0.00002824943],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003667714,0.9967017,0.0008747683,0.0002413328,0.0002451889,0.000009521723,0.00003873415,0.0000247843,0.001497232],"genre_scores_gemma":[0.001749857,0.9960966,0.0008361049,0.0002363822,0.00008936557,0.000009091362,0.0000717336,0.000004649386,0.0009062224],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001824719,"threshold_uncertainty_score":0.004916847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03921604636329762,"score_gpt":0.3483246632926454,"score_spread":0.3091086169293478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}