{"id":"W3098075819","doi":"10.3390/life10110295","title":"Genome Editing by CRISPR-Cas: A Game Change in the Genetic Manipulation of Chlamydomonas","year":2020,"lang":"en","type":"review","venue":"Life","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Mitacs; Canada Research Chairs","keywords":"CRISPR; Genome editing; Chlamydomonas reinhardtii; Transcription activator-like effector nuclease; Biology; Computational biology; Chlamydomonas; Zinc finger nuclease; Cas9; Genome; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001367372,0.0002594927,0.0005458667,0.00005308908,0.00001768019,0.00001613322,0.0003293672,0.0002403529,0.00001294398],"category_scores_gemma":[0.00007774698,0.000207467,0.0002035889,0.0001736984,0.0000233277,0.000001707212,0.00009780963,0.00018046,0.000009090198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001305139,"about_ca_system_score_gemma":0.00004621669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002958064,"about_ca_topic_score_gemma":0.00001466953,"domain_scores_codex":[0.9987587,0.00008637334,0.0004587164,0.0003291442,0.0001526363,0.0002143689],"domain_scores_gemma":[0.999388,0.0000210673,0.0001791936,0.0003304108,0.00002022787,0.00006109405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001931078,0.0001513999,0.000234259,0.02090631,0.0003841038,0.0000531357,0.001599646,0.0001574526,0.006411013,0.00004281415,0.002156482,0.9678841],"study_design_scores_gemma":[0.0001193773,0.00007490359,0.0004375766,0.0004560927,0.000123519,0.00002000598,0.00003283553,0.00006588663,0.000139893,0.000002167475,0.9983103,0.0002174035],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003882177,0.9967696,0.001906806,0.00005581762,0.0001381388,0.0005853536,0.00005645056,0.000007150592,0.00009247709],"genre_scores_gemma":[0.01804828,0.9795695,0.0001217244,0.0001562643,0.001429679,0.000161273,0.0004449552,0.00004841601,0.00001994037],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9961538,"threshold_uncertainty_score":0.8460258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03921604636329762,"score_gpt":0.3483246632926454,"score_spread":0.3091086169293478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}