{"id":"W3098209900","doi":"10.1002/anie.202012673","title":"The pH‐Induced Selectivity Between Cysteine or Histidine Coordinated Heme in an Artificial α‐Helical Metalloprotein","year":2020,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Porphyrin and Phthalocyanine Chemistry","field":"Materials Science","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"National Institute of General Medical Sciences; National Institute of Environmental Health Sciences; Centre National de la Recherche Scientifique; National Institutes of Health; National Science Foundation","keywords":"Heme; Chemistry; Histidine; Hemeprotein; Cofactor; Metalloprotein; Redox; Cysteine; Hemin; Copper protein; Stereochemistry; Combinatorial chemistry; Inorganic chemistry; Metal; Biochemistry; Amino acid; Organic chemistry; Copper; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001764079,0.0001283221,0.0001030281,0.00005507257,0.0000635902,0.0002021934,0.0001660372,0.0001482322,0.0003233853],"category_scores_gemma":[0.000153163,0.00009714607,0.00007118688,0.00005597383,0.0001998385,0.0001235476,0.000131739,0.0001995361,0.0001489035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001419597,"about_ca_system_score_gemma":0.00008155603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001014378,"about_ca_topic_score_gemma":0.0001557628,"domain_scores_codex":[0.9999015,0.00002807623,0.000007817431,0.00002489699,0.00002058342,0.00001705297],"domain_scores_gemma":[0.9998603,0.00002477959,0.00004723311,0.00001794097,0.00001395332,0.00003581454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005264375,0.00001058629,0.00007924513,0.00000996019,0.000001502327,0.00002245827,0.000008346507,0.000111799,0.9992622,0.00006738371,0.00001016917,0.0003637065],"study_design_scores_gemma":[0.00001200399,0.0001826341,0.0008955888,0.000001424104,0.000003989749,0.0001155741,0.00000755719,0.001255948,0.9966673,0.00003075631,0.0008234809,0.000003771047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967363,0.00006296182,0.002760388,0.00002482218,0.000006723008,0.00001173268,0.00004063954,0.00003451652,0.0003217706],"genre_scores_gemma":[0.9969746,0.00003765968,0.002485272,0.00001084,0.000002341879,0.000005725931,0.00004224975,0.000005319623,0.0004359593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003233853,"threshold_uncertainty_score":0.001081824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06353746884032689,"score_gpt":0.304482976655409,"score_spread":0.2409455078150821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}