{"id":"W3098218729","doi":"10.1523/jneurosci.1211-20.2020","title":"Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2","year":2020,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Queen's University","funders":"National Institute of Dental and Craniofacial Research; Takeda Pharmaceuticals International; National Institutes of Health; Cancer Australia; Australian Research Council; Crohn's and Colitis Canada; University of Melbourne; National Institute of Neurological Disorders and Stroke; Centre of Excellence for Environmental Decisions, Australian Research Council; National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Department of Defense","keywords":"Receptor; Adenylyl cyclase; Protease-activated receptor; Protease-activated receptor 2; Cancer research; Endocrinology; Nociception; Internal medicine; TRPV1; Cancer; Protein kinase A; Chemistry; Kinase; Biology; Cell biology; Transient receptor potential channel; Medicine; Platelet; Thrombin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003487901,0.000180008,0.0003643342,0.00008476755,0.0001316246,0.0000583208,0.0007786261,0.00004628437,0.00005313017],"category_scores_gemma":[0.002729556,0.0001384555,0.0001254476,0.0008226611,0.000409387,0.0004934265,0.0001069067,0.0004510312,0.000005332749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002172828,"about_ca_system_score_gemma":0.0001822007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000194109,"about_ca_topic_score_gemma":2.443719e-7,"domain_scores_codex":[0.997651,0.0005405735,0.0005555999,0.0003913968,0.0005297335,0.0003316503],"domain_scores_gemma":[0.9984485,0.0002325736,0.0008064553,0.0001317564,0.0001037829,0.0002769702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001709877,0.0001128277,0.0001267532,0.00001896415,0.000001196169,0.00005085447,0.00009219744,0.0001015262,0.9931416,0.00004204742,0.003994016,0.002147027],"study_design_scores_gemma":[0.0003668393,0.001829958,0.001102,0.00004224799,0.000005279909,0.00002170991,0.00002800466,0.0003124884,0.9792817,0.0000441788,0.01682968,0.0001358865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968197,0.00003031664,0.00007434381,0.002416143,0.000375034,0.0001617787,0.00003701747,0.0000213187,0.00006434042],"genre_scores_gemma":[0.990714,0.0001114823,0.00007944409,0.008899449,0.0001185075,0.00000345354,1.91085e-7,0.00001973744,0.00005371235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01385987,"threshold_uncertainty_score":0.5646052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09215079512773912,"score_gpt":0.3031773921099058,"score_spread":0.2110265969821667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}