{"id":"W3098218729","doi":"10.1523/jneurosci.1211-20.2020","title":"Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2","year":2020,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Queen's University","funders":"National Institute of Dental and Craniofacial Research; Takeda Pharmaceuticals International; National Institutes of Health; Cancer Australia; Australian Research Council; Crohn's and Colitis Canada; University of Melbourne; National Institute of Neurological Disorders and Stroke; Centre of Excellence for Environmental Decisions, Australian Research Council; National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Department of Defense","keywords":"Receptor; Adenylyl cyclase; Protease-activated receptor; Protease-activated receptor 2; Cancer research; Endocrinology; Nociception; Internal medicine; TRPV1; Cancer; Protein kinase A; Chemistry; Kinase; Biology; Cell biology; Transient receptor potential channel; Medicine; Platelet; Thrombin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009704237,0.0003680961,0.0002722597,0.0002065203,0.000132099,0.0002213096,0.0001491149,0.0002387763,0.001351816],"category_scores_gemma":[0.0001135531,0.0001390865,0.0003121286,0.0001336226,0.0001981772,0.0001686206,0.0002085619,0.0007651107,0.000196736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002552599,"about_ca_system_score_gemma":0.000151514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003256717,"about_ca_topic_score_gemma":0.0006552456,"domain_scores_codex":[0.9998503,0.0000292163,0.000009802059,0.00001814563,0.00002702043,0.00006549495],"domain_scores_gemma":[0.9999453,0.000009547236,0.00001858024,0.000006344655,0.00000341861,0.00001682333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003040846,0.00008221328,0.0001256638,0.00002682106,0.000005145583,0.00006761919,0.00001098708,0.0000327624,0.9984602,0.00004328499,0.00003613225,0.0008051319],"study_design_scores_gemma":[0.0002240079,0.004794324,0.01389195,0.00001684585,0.00005647863,0.0007091548,0.000116938,0.001596354,0.9760514,0.0001370145,0.002392481,0.00001306233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978077,0.0006802296,0.0004687026,0.00008369145,0.00002937129,0.0000384583,0.0001319233,0.0000256984,0.00073427],"genre_scores_gemma":[0.997381,0.0006488304,0.0004678621,0.00008059293,0.00001501395,0.00007024929,0.0001973705,0.000005335437,0.00113374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001351816,"threshold_uncertainty_score":0.004522204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09215079512773912,"score_gpt":0.3031773921099058,"score_spread":0.2110265969821667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}