{"id":"W3098430919","doi":"10.1056/nejmoa2025797","title":"Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure","year":2020,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":644,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Libin Cardiovascular Institute of Alberta; Université de Montréal; University of Calgary","funders":"Cumming School of Medicine, University of Calgary; National Health Commission of the People's Republic of China; Institut de Cardiologie de Montréal; Servier; Masarykova Univerzita; University of Cape Town; Faculdade de Medicina da Universidade de São Paulo; Medizinische Universität Wien; National and Kapodistrian University of Athens; Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu; Chinese Academy of Medical Sciences; Institut National de la Santé et de la Recherche Médicale; Universität des Saarlandes; Det Sundhedsvidenskabelige Fakultet, Københavns Universitet; Peking Union Medical College; University of Bern; Universität Wien; Faculty of Health and Medical Sciences, University of Western Australia; Rijksuniversiteit Groningen; Dokuz Eylül Üniversitesi; Gentofte Hospital; Università degli Studi di Brescia; Université de Lorraine; University of Minnesota; University of Glasgow; Imperial College London; Inselspital, Universitätsspital Bern; Fuwai Hospital, Chinese Academy of Medical Sciences; Universidade Nova de Lisboa; Brigham and Women's Hospital; British Heart Foundation; Cytokinetics; Lomonosov Moscow State University; Universidade da Coruña; Universidade de São Paulo; Université de Montréal; Pontificia Universidad Católica de Chile; Amgen","keywords":"Cardiology; Medicine; Heart failure; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005086843,0.0002443036,0.0004746115,0.0001360939,0.00008534789,0.0001395486,0.0001368353,0.000195679,0.001147742],"category_scores_gemma":[0.0006756365,0.000101261,0.0002152251,0.000107477,0.0001886922,0.0001067345,0.0001737468,0.0004390769,0.0001138322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001759558,"about_ca_system_score_gemma":0.0001690554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001863725,"about_ca_topic_score_gemma":0.0004429437,"domain_scores_codex":[0.9998505,0.00006875698,0.00001250853,0.00001696269,0.00001960473,0.00003170832],"domain_scores_gemma":[0.9997696,0.00006498734,0.00008976347,0.00000742866,0.00001030765,0.00005794715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4118967,0.0081339,0.05630767,0.002088185,0.0009419219,0.0005791629,0.0002307057,0.003021126,0.1479468,0.0002547839,0.002258959,0.36634],"study_design_scores_gemma":[0.1341322,0.5448859,0.2786472,0.0005872293,0.001136233,0.001831156,0.0001723643,0.005558705,0.02565333,0.0003099425,0.007040958,0.00004472075],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995976,0.003264395,0.0001142435,0.0001392948,0.00002905645,0.00005855291,0.00002672444,0.000007326241,0.0003844554],"genre_scores_gemma":[0.9985247,0.0009886412,0.0001344374,0.00008931343,0.00004862472,0.00003956375,0.00003626514,9.737347e-7,0.0001376602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001147742,"threshold_uncertainty_score":0.003839612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01734415792506544,"score_gpt":0.2533358261233003,"score_spread":0.2359916681982349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}