{"id":"W3098430919","doi":"10.1056/nejmoa2025797","title":"Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure","year":2020,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":644,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Libin Cardiovascular Institute of Alberta; Université de Montréal; University of Calgary","funders":"Cumming School of Medicine, University of Calgary; National Health Commission of the People's Republic of China; Institut de Cardiologie de Montréal; Servier; Masarykova Univerzita; University of Cape Town; Faculdade de Medicina da Universidade de São Paulo; Medizinische Universität Wien; National and Kapodistrian University of Athens; Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu; Chinese Academy of Medical Sciences; Institut National de la Santé et de la Recherche Médicale; Universität des Saarlandes; Det Sundhedsvidenskabelige Fakultet, Københavns Universitet; Peking Union Medical College; University of Bern; Universität Wien; Faculty of Health and Medical Sciences, University of Western Australia; Rijksuniversiteit Groningen; Dokuz Eylül Üniversitesi; Gentofte Hospital; Università degli Studi di Brescia; Université de Lorraine; University of Minnesota; University of Glasgow; Imperial College London; Inselspital, Universitätsspital Bern; Fuwai Hospital, Chinese Academy of Medical Sciences; Universidade Nova de Lisboa; Brigham and Women's Hospital; British Heart Foundation; Cytokinetics; Lomonosov Moscow State University; Universidade da Coruña; Universidade de São Paulo; Université de Montréal; Pontificia Universidad Católica de Chile; Amgen","keywords":"Cardiology; Medicine; Heart failure; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004444143,0.0001623591,0.0006651236,0.0002193157,0.00002335967,0.000007735141,0.00005774608,0.00005311462,0.0001334497],"category_scores_gemma":[0.000180247,0.00009384098,0.00006676278,0.000387289,0.00004185698,0.0001245381,0.00001262251,0.000339393,0.000009002832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009247349,"about_ca_system_score_gemma":0.0001816674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001300254,"about_ca_topic_score_gemma":0.00003128465,"domain_scores_codex":[0.9986305,0.00008931082,0.0004063703,0.0001445899,0.0005364192,0.0001927734],"domain_scores_gemma":[0.9991164,0.00009299965,0.0001533151,0.0001206047,0.0001148011,0.0004019061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.009814698,0.0004876513,0.2357001,0.0007493435,0.001531718,0.002071514,0.0155225,0.0002583297,0.05805126,0.0008924541,0.5697743,0.1051461],"study_design_scores_gemma":[0.07016932,0.006476935,0.03204343,0.001679195,0.0005337229,0.0003781719,0.001340586,0.00005700304,0.002244084,0.00005643894,0.8848521,0.0001690067],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5694078,0.0007082036,0.0007443519,0.4274893,0.000169243,0.000449604,6.811847e-7,0.00002595491,0.001004976],"genre_scores_gemma":[0.9922363,0.00009795897,0.002241328,0.002360056,0.002821456,0.000002969046,0.000007205867,0.00001911521,0.0002135741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4251292,"threshold_uncertainty_score":0.3826724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01734415792506544,"score_gpt":0.2533358261233003,"score_spread":0.2359916681982349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}