{"id":"W3098481241","doi":"10.1136/ijgc-2020-igcs.287","title":"335 Low BRCA 1/2 germline mutation rate in a french canadian population","year":2020,"lang":"en","type":"article","venue":"International Journal of Gynecological Cancer","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôtel-Dieu de Québec","funders":"","keywords":"MUTYH; Medicine; Population; Oncology; Germline mutation; Lynch syndrome; BRCA mutation; MSH6; Serous carcinoma; Frameshift mutation; Ovarian cancer; Internal medicine; Cancer; Serous fluid; Cancer research; Mutation; Colorectal cancer; Biology; Genetics; DNA mismatch repair; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004786412,0.0007819046,0.0006784355,0.002860689,0.005279976,0.001618626,0.001261896,0.00094061,0.005750776],"category_scores_gemma":[0.001420289,0.0004925604,0.0008610766,0.003419909,0.001232579,0.0003689148,0.000682644,0.0009268682,0.0004787724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01321641,"about_ca_system_score_gemma":0.01213397,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9780894,"about_ca_topic_score_gemma":0.9714436,"domain_scores_codex":[0.9993016,0.00006124017,0.00003140728,0.000158662,0.0001208871,0.0003261571],"domain_scores_gemma":[0.9992954,0.00006713392,0.00009960792,0.00002736792,0.0002751328,0.0002353789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002360581,0.0001489832,0.9745182,0.00007692944,0.0001577806,0.002681819,0.005413902,0.0002405335,0.0011598,0.0009683301,0.002532329,0.01186526],"study_design_scores_gemma":[0.00002840062,0.0001462649,0.9862807,0.00007331518,0.0001181106,0.002120568,0.006436597,0.0004348815,0.0001037591,0.0002224101,0.003980368,0.0000547107],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944292,0.0008499814,0.0002303527,0.00053542,0.00002184,0.00002830211,0.0009602422,0.00001751636,0.002927294],"genre_scores_gemma":[0.9958912,0.0006554334,0.000251438,0.0002171371,0.00001791456,0.00001738262,0.0003857043,0.0000130946,0.002550544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02191061,"threshold_uncertainty_score":0.09589219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01618530530456067,"score_gpt":0.299249474511747,"score_spread":0.2830641692071864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}