{"id":"W3098571689","doi":"10.1101/354316","title":"Spatial Organization of Rho GTPase signaling by RhoGEF/RhoGAP proteins","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research; University of Toronto; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"Biotechnology and Biological Sciences Research Council; Terry Fox Research Institute; Stand Up To Cancer; Krembil Foundation; National Human Genome Research Institute; Canada Excellence Research Chairs, Government of Canada; Ontario Genomics; National Institutes of Health; Cancer Research UK; Canadian Institutes of Health Research; Genome Canada; Government of Ontario; Avon Foundation for Women","keywords":"Crosstalk; CDC42; Cell biology; GTPase; Biology; RHOA; Interactome; Guanine nucleotide exchange factor; Rac GTP-Binding Proteins; Signaling proteins; GTPase-activating protein; Signal transduction; Morphogenesis; RAC1; G protein; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006678973,0.0001311004,0.0001100517,0.0002204278,0.0001804368,0.0003516742,0.0001437136,0.0001236418,0.000438828],"category_scores_gemma":[0.00007061563,0.0001457337,0.0001500561,0.0001228519,0.0002397886,0.0001934827,0.0001911953,0.0002330987,0.0002320226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002926937,"about_ca_system_score_gemma":0.000174361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005677379,"about_ca_topic_score_gemma":0.0008478162,"domain_scores_codex":[0.9999199,0.00001491038,0.000003261057,0.00002510241,0.0000192459,0.0000176462],"domain_scores_gemma":[0.9999654,0.000004090905,0.00001259117,0.000006403498,0.000005602504,0.000005859605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004357651,0.000007246217,0.0006250205,0.00001928201,0.000004419459,0.00005983126,0.00001436353,0.000563414,0.9959585,0.0009605461,0.00005141207,0.001692423],"study_design_scores_gemma":[0.00001495948,0.00005802196,0.03259826,0.00001673643,0.00002250765,0.0005116478,0.0001428384,0.01479814,0.9451637,0.001664907,0.004993555,0.00001471483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879718,0.001464265,0.007783363,0.00009101084,0.000007850471,0.000008422775,0.0001583935,0.00006903312,0.002445892],"genre_scores_gemma":[0.9964706,0.0002801641,0.002319666,0.0000135943,0.000002443753,0.000005791,0.00008911134,0.000009369649,0.0008092236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005677379,"threshold_uncertainty_score":0.002123594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00751855629708011,"score_gpt":0.2079247878635176,"score_spread":0.2004062315664375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}