{"id":"W3098571689","doi":"10.1101/354316","title":"Spatial Organization of Rho GTPase signaling by RhoGEF/RhoGAP proteins","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research; University of Toronto; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"Biotechnology and Biological Sciences Research Council; Terry Fox Research Institute; Stand Up To Cancer; Krembil Foundation; National Human Genome Research Institute; Canada Excellence Research Chairs, Government of Canada; Ontario Genomics; National Institutes of Health; Cancer Research UK; Canadian Institutes of Health Research; Genome Canada; Government of Ontario; Avon Foundation for Women","keywords":"Crosstalk; CDC42; Cell biology; GTPase; Biology; RHOA; Interactome; Guanine nucleotide exchange factor; Rac GTP-Binding Proteins; Signaling proteins; GTPase-activating protein; Signal transduction; Morphogenesis; RAC1; G protein; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005197102,0.0004531125,0.0004462682,0.0002024253,0.00009402321,0.00006788214,0.0004124122,0.0007449224,0.00009334483],"category_scores_gemma":[0.0003755888,0.0005238097,0.0001204822,0.0004069131,0.0001505063,0.00001069293,0.0004253975,0.0003127678,0.00001560749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008048369,"about_ca_system_score_gemma":0.000682194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001085499,"about_ca_topic_score_gemma":0.000007361194,"domain_scores_codex":[0.9975352,0.0001650819,0.0006655166,0.0009020608,0.0003294669,0.000402673],"domain_scores_gemma":[0.9976062,0.00001057284,0.0005709061,0.0009115328,0.0007339533,0.0001668775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000417628,0.0001446492,0.007144011,0.0002607832,0.00006373516,0.0000077904,0.00000463936,0.0001407094,0.9919319,0.00004591756,0.0002108157,0.000003312975],"study_design_scores_gemma":[0.0006343665,0.00009783907,0.004231582,0.0003508994,0.0000425473,1.88207e-8,0.000001503136,0.0002057503,0.9922967,0.0000016883,0.001598402,0.0005386962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794157,0.0008685394,0.01805175,0.00005629937,0.0003116167,0.0009538048,0.0002661247,0.00006922647,0.000006959944],"genre_scores_gemma":[0.9954374,0.00009904906,0.003597816,0.00008517487,0.0005513382,0.00007907015,0.00001428174,0.0001282397,0.000007621582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01602172,"threshold_uncertainty_score":0.9997213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00751855629708011,"score_gpt":0.2079247878635176,"score_spread":0.2004062315664375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}