{"id":"W3098614651","doi":"10.1101/2020.11.18.388553","title":"Preclinical validation of a second generation leishmanization vaccine against vector transmitted fatal visceral leishmaniasis","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Global Health Innovative Technology Fund","keywords":"Visceral leishmaniasis; Immune system; Immunology; Leishmania donovani; Proinflammatory cytokine; Leishmania; Spleen; Leishmaniasis; Chemokine; Medicine; Immunization; Biology; Virology; Inflammation; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004475923,0.0005694968,0.0004927097,0.0002388965,0.0001321622,0.0004223899,0.0004925559,0.0006346421,0.001771817],"category_scores_gemma":[0.0001970178,0.000178737,0.0003399315,0.00009770469,0.0002660324,0.0002927018,0.0002201269,0.001506765,0.0003312458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002959215,"about_ca_system_score_gemma":0.0003821596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004383963,"about_ca_topic_score_gemma":0.0004882756,"domain_scores_codex":[0.9998378,0.00003442125,0.00001047766,0.00002881109,0.00003785788,0.00005057135],"domain_scores_gemma":[0.9998583,0.00001770975,0.00003047273,0.00001580087,0.00003108524,0.00004661182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00130538,0.002703918,0.0003349581,0.0003289685,0.00004286226,0.00007151135,0.00004601695,0.0006989764,0.9866846,0.000213099,0.0005149041,0.007054771],"study_design_scores_gemma":[0.001328402,0.1053685,0.003553688,0.00008081347,0.0002181681,0.0004772652,0.00007868348,0.002154654,0.8740872,0.0001958502,0.01243823,0.00001853309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901984,0.001519121,0.004552639,0.0003432133,0.0001725914,0.0006370092,0.0009547117,0.0001630737,0.001459323],"genre_scores_gemma":[0.9919448,0.001197808,0.0024932,0.000175617,0.00003209849,0.0004458312,0.001305765,0.00001753642,0.002387297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001771817,"threshold_uncertainty_score":0.005927265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04290707255337798,"score_gpt":0.2871779518183256,"score_spread":0.2442708792649476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}