{"id":"W3098627931","doi":"10.1101/388165","title":"Expanding Parkinson’s disease genetics: novel risk loci, genomic context, causal insights and heritable risk","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Mendelian randomization; Biology; Genome-wide association study; Genetics; Genetic architecture; Context (archaeology); Disease; Single-nucleotide polymorphism; Genetic association; Mendelian inheritance; Biobank; Gene; Quantitative trait locus; Evolutionary biology; Genetic variants; Genotype; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003993747,0.001029581,0.001114945,0.0003739947,0.000525168,0.000276069,0.0003289556,0.0005590499,0.000124833],"category_scores_gemma":[0.0002370154,0.001010299,0.0002868739,0.0002624936,0.0002772725,0.0001445511,0.00067867,0.0008363799,0.0001280142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006776783,"about_ca_system_score_gemma":0.00091478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003256965,"about_ca_topic_score_gemma":0.00001871946,"domain_scores_codex":[0.9957551,0.000180572,0.0006913781,0.001935484,0.000558732,0.0008787807],"domain_scores_gemma":[0.9956667,0.00007253606,0.0007638028,0.001497088,0.0004284851,0.001571356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001378664,0.002160282,0.7767573,0.001387176,0.003307486,0.001031901,0.0001221768,0.00004435385,0.2126264,0.000181272,0.0009102569,0.00009265914],"study_design_scores_gemma":[0.004596856,0.0002792707,0.9148572,0.0007682365,0.002920039,1.477571e-7,0.00001376262,0.00160277,0.03445898,0.00002326467,0.03928149,0.001197972],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9734076,0.01991941,0.001960787,0.00003796744,0.001017335,0.001570562,0.001715231,0.0003606062,0.00001045387],"genre_scores_gemma":[0.9850655,0.007564704,0.005463819,0.0002230942,0.001000201,0.0003821415,0.000004142467,0.0002739575,0.00002248399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1781675,"threshold_uncertainty_score":0.9992347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01605741581703032,"score_gpt":0.2335633876661556,"score_spread":0.2175059718491253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}