{"id":"W3098627931","doi":"10.1101/388165","title":"Expanding Parkinson’s disease genetics: novel risk loci, genomic context, causal insights and heritable risk","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Mendelian randomization; Biology; Genome-wide association study; Genetics; Genetic architecture; Context (archaeology); Disease; Single-nucleotide polymorphism; Genetic association; Mendelian inheritance; Biobank; Gene; Quantitative trait locus; Evolutionary biology; Genetic variants; Genotype; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00141588,0.0004380589,0.0006859335,0.001016648,0.0003611202,0.0009855223,0.0003346893,0.0004898487,0.002505874],"category_scores_gemma":[0.002585735,0.0002161729,0.000440086,0.0009819514,0.0007479407,0.0003388985,0.0008906577,0.0007401331,0.0002301839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002715222,"about_ca_system_score_gemma":0.0004232139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001177049,"about_ca_topic_score_gemma":0.001791428,"domain_scores_codex":[0.9991191,0.0002957379,0.00007130024,0.0002811183,0.0001654105,0.00006721239],"domain_scores_gemma":[0.9987392,0.0006315831,0.0003027755,0.0001790585,0.00007274391,0.00007473007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00150545,0.0001907861,0.8061149,0.0005821766,0.00146042,0.005490087,0.001132576,0.002756534,0.1015022,0.003274445,0.001791187,0.07419938],"study_design_scores_gemma":[0.0001855023,0.0002631179,0.95835,0.0001829277,0.001033821,0.004873054,0.0003813867,0.003307797,0.01323663,0.01165074,0.006486418,0.00004853564],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821396,0.00517901,0.00860745,0.001325396,0.00004903643,0.0000210188,0.001165283,0.00007183074,0.001441333],"genre_scores_gemma":[0.9947548,0.0009838607,0.0033723,0.0001511413,0.00006066598,0.00001132691,0.0003681268,0.00001326108,0.0002844332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002505874,"threshold_uncertainty_score":0.008382976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01605741581703032,"score_gpt":0.2335633876661556,"score_spread":0.2175059718491253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}