{"id":"W3098746230","doi":"10.1177/0897190020972208","title":"Reduction in Tamoxifen Metabolites Endoxifen and N-desmethyltamoxifen With Chronic Administration of Low Dose Cannabidiol: A CYP3A4 and CYP2D6 Drug Interaction","year":2020,"lang":"en","type":"article","venue":"Journal of Pharmacy Practice","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"","keywords":"Medicine; Tamoxifen; CYP2D6; Pharmacology; CYP3A4; Discontinuation; Adverse effect; Cannabidiol; Active metabolite; Drug; Pharmacokinetics; Drug interaction; Metabolite; Breast cancer; Internal medicine; Cancer; Cytochrome P450; Metabolism; Cannabis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001984834,0.0001894257,0.0003192486,0.0002068593,0.0001549336,0.0001963544,0.000177896,0.0002944904,0.001352205],"category_scores_gemma":[0.0004934029,0.00007720027,0.0004038434,0.0001919974,0.0001351061,0.00009488965,0.0001182912,0.0003702937,0.0001639034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002444269,"about_ca_system_score_gemma":0.0001836626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006100839,"about_ca_topic_score_gemma":0.001257833,"domain_scores_codex":[0.9997938,0.00004751205,0.00001804925,0.00003504021,0.00008254833,0.00002302718],"domain_scores_gemma":[0.9997966,0.00004669833,0.00008497155,0.00001793254,0.00002926113,0.00002446384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006361619,0.001107677,0.152186,0.0005143198,0.000534527,0.005118663,0.0001966152,0.0002668712,0.6708165,0.000227111,0.001073283,0.1615968],"study_design_scores_gemma":[0.000475424,0.01549378,0.6322861,0.00006139435,0.0008662286,0.02485701,0.0002746373,0.001987993,0.3008533,0.0003595699,0.0224572,0.00002744215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911029,0.005549573,0.001342297,0.0004932293,0.00003267123,0.00004884391,0.0001703006,0.00003987383,0.001220253],"genre_scores_gemma":[0.9967071,0.0009876154,0.0009066638,0.0001577505,0.00002614634,0.00001746077,0.0001329486,0.000005225394,0.001058981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001352205,"threshold_uncertainty_score":0.004523516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02713308975102493,"score_gpt":0.3679583128279595,"score_spread":0.3408252230769346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}