{"id":"W3098965480","doi":"10.3389/fcell.2020.583919","title":"Regenerative Intestinal Stem Cells Induced by Acute and Chronic Injury: The Saving Grace of the Epithelium?","year":2020,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Children's Hospital","funders":"Mitacs","keywords":"Stem cell; Intestinal epithelium; Regeneration (biology); Biology; Population; Inflammation; Inflammatory bowel disease; Homeostasis; Cell biology; Immunology; Intestinal mucosa; Epithelium; Regenerative process; Progenitor cell; Disease; Medicine; Pathology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000376004,0.0005348804,0.0009206464,0.001202989,0.0002214721,0.0008944367,0.000587995,0.000993107,0.003127451],"category_scores_gemma":[0.0005138485,0.0001478358,0.0003204247,0.00126483,0.0005043371,0.001453,0.00063019,0.001640768,0.001916592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004158877,"about_ca_system_score_gemma":0.0007167957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004768073,"about_ca_topic_score_gemma":0.0009441017,"domain_scores_codex":[0.9999007,0.00001748741,0.00001328539,0.00001731994,0.00003980949,0.00001141236],"domain_scores_gemma":[0.9998226,0.00008488635,0.00001815373,0.000007276724,0.00004480711,0.00002242133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008001206,0.00003832692,0.0001053228,0.01203522,0.00004367282,0.0001742921,0.00007327364,0.0001872268,0.002596285,0.006536067,0.03309817,0.9450321],"study_design_scores_gemma":[0.00001123679,0.00007685827,0.0004858262,0.00253841,0.00004150992,0.0009889021,0.000062192,0.00004380339,0.0005091068,0.002561344,0.9926681,0.00001261684],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001194911,0.9979637,0.0001133962,0.0005110452,0.0003303262,0.000002467179,0.00001611847,0.000007288202,0.0009362352],"genre_scores_gemma":[0.0006800113,0.9979305,0.0001293434,0.0003358193,0.0002537888,0.000004714894,0.00002779005,0.000001897251,0.0006360213],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003127451,"threshold_uncertainty_score":0.0104624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.024001703168738,"score_gpt":0.2796161120002816,"score_spread":0.2556144088315436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}