{"id":"W3099178389","doi":"10.1371/journal.pone.0241646","title":"c-Src kinase inhibits osteogenic differentiation via enhancing STAT1 stability","year":2020,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"RUNX2; Proto-oncogene tyrosine-protein kinase Src; Cell biology; STAT1; Transcription factor; Embryonic stem cell; Biology; Cellular differentiation; Small interfering RNA; STAT3; Kinase; STAT protein; Stem cell; Molecular biology; Transfection; Signal transduction; Chemistry; Cell culture; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001596476,0.0003152475,0.0002814549,0.000192367,0.0001428057,0.0002434017,0.0001505106,0.0001744533,0.001455254],"category_scores_gemma":[0.0001088779,0.00009654809,0.0002279466,0.0001679702,0.0002351966,0.0001408791,0.0001772587,0.0006507495,0.0002754999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000241488,"about_ca_system_score_gemma":0.0003385959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004926682,"about_ca_topic_score_gemma":0.001460829,"domain_scores_codex":[0.9998401,0.000020962,0.00001800506,0.00002436623,0.00005086133,0.00004562268],"domain_scores_gemma":[0.9999274,0.00001814187,0.00001808885,0.000008720934,0.00001054357,0.00001708394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001360589,0.00004854001,0.0001353345,0.00005641145,0.000005124888,0.00001953656,0.000009774106,0.00007990965,0.9971207,0.0001167292,0.00006971866,0.002202113],"study_design_scores_gemma":[0.00002393638,0.0003003972,0.002000179,0.000003757604,0.00001396143,0.0001106601,0.000009986477,0.0008979053,0.9943027,0.00003788602,0.002295441,0.000003080451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894329,0.004378313,0.002454318,0.0001821674,0.00007215396,0.00003143503,0.0003477874,0.0001133244,0.002987487],"genre_scores_gemma":[0.9939985,0.001760563,0.001254571,0.00004793738,0.00002055475,0.00002403298,0.0004686143,0.00001585946,0.002409409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001455254,"threshold_uncertainty_score":0.004868269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08570523847746916,"score_gpt":0.2475042462516766,"score_spread":0.1617990077742074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}