{"id":"W3099435449","doi":"10.1016/j.ijrobp.2020.09.022","title":"Randomized, Double-Blinded, Placebo-controlled Multicenter Adaptive Phase 1-2 Trial of GC 4419, a Dismutase Mimetic, in Combination with High Dose Stereotactic Body Radiation Therapy (SBRT) in Locally Advanced Pancreatic Cancer (PC)","year":2020,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Aegera Therapeutics (Canada)","funders":"","keywords":"Medicine; Toxicity; Placebo; Pancreatic cancer; Superoxide dismutase; Cancer; Phases of clinical research; Clinical trial; In vivo; Radiation therapy; Oncology; Internal medicine; Urology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001583888,0.002925842,0.004365079,0.0006684265,0.000708422,0.001253343,0.001409926,0.002112573,0.0100318],"category_scores_gemma":[0.001841147,0.001047253,0.001299322,0.0005579944,0.001959092,0.001336479,0.0005837409,0.003163762,0.001470304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009011449,"about_ca_system_score_gemma":0.00154158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001389401,"about_ca_topic_score_gemma":0.003028438,"domain_scores_codex":[0.9993736,0.0002948768,0.00003256083,0.0001471324,0.00004246761,0.000109429],"domain_scores_gemma":[0.9991919,0.0001953477,0.0001851582,0.00009151121,0.00005944059,0.0002766571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9871204,0.005318233,0.0001078689,0.0002095301,0.0002692386,0.00001065783,0.00002085993,0.0001614975,0.0013148,0.00007450912,0.0004226629,0.004969708],"study_design_scores_gemma":[0.9772479,0.02164876,0.0002979668,0.000008154731,0.0001066411,0.000006619723,0.0000067467,0.0001847621,0.000160861,0.00008361338,0.0002405622,0.000007386455],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784444,0.002812651,0.001563892,0.0008154067,0.00125827,0.009304328,0.001699279,0.0004775631,0.003624163],"genre_scores_gemma":[0.966123,0.00240993,0.004588227,0.002088869,0.0009137829,0.01369139,0.001738438,0.0001158084,0.008330572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0100318,"threshold_uncertainty_score":0.03355968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02749591222729757,"score_gpt":0.3466726655653187,"score_spread":0.3191767533380211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}