{"id":"W3099742144","doi":"10.1101/2020.09.06.285270","title":"EPH Receptor Tyrosine Kinases Regulate Epithelial Morphogenesis and Phosphorylate the PAR-3 Scaffold Protein to Modulate Downstream Signaling Networks","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; PROTEO","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; Université Laval","keywords":"Erythropoietin-producing hepatocellular (Eph) receptor; Ephrin; Cell biology; Receptor tyrosine kinase; Scaffold protein; Biology; Signal transduction; Cell migration; Phosphorylation; Cell signaling; Morphogenesis; Cell polarity; Cell adhesion; EPH receptor A2; Receptor; Cell; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008389902,0.0002153823,0.0001390149,0.0001974637,0.0001891492,0.0003005227,0.000101009,0.0001465419,0.001727359],"category_scores_gemma":[0.00008002495,0.00009556698,0.0002689832,0.0001448215,0.0001380912,0.0002297717,0.0002639133,0.0002857856,0.0006377049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002832062,"about_ca_system_score_gemma":0.0001311164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003777938,"about_ca_topic_score_gemma":0.0004405327,"domain_scores_codex":[0.9998963,0.00001647253,0.000005084656,0.00002001429,0.00002953376,0.00003257003],"domain_scores_gemma":[0.9999465,0.000005987108,0.00001885075,0.000004605358,0.000009318281,0.0000147509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005469279,0.000007353487,0.0008675468,0.00002831308,0.000008624869,0.00007230336,0.00000774795,0.0001010393,0.9968839,0.0002467906,0.0001161861,0.001605455],"study_design_scores_gemma":[0.00001803271,0.00009468326,0.06197743,0.000010897,0.00003697384,0.0006086484,0.000100554,0.00517364,0.9245908,0.0004828254,0.006897012,0.000008486927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868445,0.002189425,0.006327678,0.0001884828,0.00002897753,0.00002632851,0.000683348,0.0001105033,0.003600758],"genre_scores_gemma":[0.9947813,0.0009711084,0.002065291,0.00004565555,0.000009301833,0.00001402079,0.0004869364,0.00001498154,0.00161133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001727359,"threshold_uncertainty_score":0.005778611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02159145924642942,"score_gpt":0.2162148258051239,"score_spread":0.1946233665586945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}