{"id":"W3099769256","doi":"10.1101/2020.11.09.374793","title":"Stable <i>DNMT3L</i> Overexpression in SH-SY5Y Neurons Recreates a Facet of the Genome-Wide Down Syndrome DNA Methylation Signature","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Intellectual and Developmental Disabilities Research Center; University of California, Davis; National Institutes of Health","keywords":"DNA methylation; Biology; Differentially methylated regions; Epigenetics; Chromatin; Genetics; CpG site; H3K4me3; Methylation; Bisulfite sequencing; Molecular biology; Gene; Gene expression; Promoter","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001107479,0.0002864534,0.000236311,0.0001504887,0.0001560655,0.0003166288,0.0002397426,0.0002243492,0.001214341],"category_scores_gemma":[0.00007369963,0.0001328318,0.000273983,0.000105117,0.0002976572,0.0001540254,0.0002776093,0.0005882137,0.0003635164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004277478,"about_ca_system_score_gemma":0.0002454884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002324905,"about_ca_topic_score_gemma":0.003274781,"domain_scores_codex":[0.9998986,0.000007813353,0.00001804523,0.00002727851,0.00002612005,0.00002226363],"domain_scores_gemma":[0.9999125,0.00001155967,0.00002874386,0.00001317456,0.000007668893,0.00002645358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001844091,0.000003738529,0.0001171505,0.000008705697,0.000002865443,0.00001780942,0.000003916204,0.00003517361,0.9995503,0.0000411287,0.00001516263,0.0001855858],"study_design_scores_gemma":[0.00001018446,0.00005556097,0.003562463,0.000003640406,0.00001453713,0.00009133892,0.00002159855,0.001077161,0.9939126,0.00003184867,0.001216463,0.000002617202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942373,0.000323893,0.003015503,0.00009280115,0.00003398093,0.0000198667,0.001274674,0.0001652094,0.0008367204],"genre_scores_gemma":[0.9952809,0.0002161889,0.001977078,0.00003602012,0.000003918257,0.00002664112,0.0006648168,0.00004774781,0.001746594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002324905,"threshold_uncertainty_score":0.004622698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01206156717088644,"score_gpt":0.2167916884981324,"score_spread":0.204730121327246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}