{"id":"W3099771665","doi":"10.1073/pnas.2009253117","title":"Safety concerns regarding concomitant use of tocilizumab and glucocorticoids in COVID-19 patients","year":2020,"lang":"en","type":"letter","venue":"Proceedings of the National Academy of Sciences","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; University Health Network","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Tocilizumab; Coronavirus disease 2019 (COVID-19); Concomitant; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Medicine; Virology; Internal medicine; Outbreak","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001066698,0.0001604847,0.000449852,0.0003148928,0.001442868,0.0009122733,0.0004484633,0.006029063,0.002311719],"category_scores_gemma":[0.007930112,0.0001192061,0.0003650154,0.0003518923,0.0007536537,0.0005022932,0.0003122111,0.003837211,0.0009263848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001975758,"about_ca_system_score_gemma":0.0009966908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002129115,"about_ca_topic_score_gemma":0.003991575,"domain_scores_codex":[0.9993082,0.0002982797,0.0001137139,0.00005417792,0.000134858,0.00009063987],"domain_scores_gemma":[0.9967134,0.001828347,0.0005083724,0.0001417345,0.000355632,0.0004524383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00148665,0.0003698309,0.1143393,0.0003693586,0.0001416026,0.3033438,0.001763831,0.0005083464,0.004536512,0.00517979,0.4127256,0.1552354],"study_design_scores_gemma":[0.0007309161,0.001964436,0.09828612,0.001506632,0.0002914699,0.478469,0.004091945,0.004669862,0.00423772,0.01679531,0.388786,0.000170667],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1330891,0.007019202,0.0007999787,0.826858,0.005459404,0.00008620976,0.0001499217,0.0001298774,0.0264082],"genre_scores_gemma":[0.6466959,0.00433629,0.0009530725,0.3288326,0.01353975,0.00007281974,0.000132116,0.00002977166,0.005407519],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.006029063,"threshold_uncertainty_score":0.01433522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1537173910464787,"score_gpt":0.4243882496016566,"score_spread":0.2706708585551779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}