{"id":"W3099857122","doi":"10.1073/pnas.2016064117","title":"REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks","year":2020,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; Alberta Emerald Foundation; National Institute of General Medical Sciences; National Center for Advancing Translational Sciences; Emerald Foundation; Ludwig Center for Molecular Oncology; National Science Foundation; Damon Runyon Cancer Research Foundation; Massachusetts Institute of Technology; Georgia Clinical and Translational Science Alliance; Howard Hughes Medical Institute; National Cancer Institute; Ludwig Center at Harvard","keywords":"Cisplatin; Senescence; DNA damage; Apoptosis; Cancer research; Biology; Cell biology; Lamin; Molecular biology; Chemotherapy; Immunology; DNA; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001263646,0.0002868109,0.0003247583,0.0001944998,0.00007961301,0.000215523,0.000288431,0.0002493369,0.001397941],"category_scores_gemma":[0.0001130703,0.0001088639,0.0002097663,0.0001086963,0.0001339419,0.0001596974,0.0001152213,0.000740639,0.0003662415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000198991,"about_ca_system_score_gemma":0.0002151042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003170747,"about_ca_topic_score_gemma":0.0007284911,"domain_scores_codex":[0.9999015,0.00001937399,0.00001467489,0.00001712685,0.0000244417,0.00002282074],"domain_scores_gemma":[0.9999193,0.00001683463,0.00001688374,0.00001398852,0.00001068142,0.00002224399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003597555,0.0001623275,0.0001360414,0.00005276596,0.00001106575,0.00002677003,0.0000101014,0.0001967543,0.995945,0.00006083329,0.0000905217,0.00294807],"study_design_scores_gemma":[0.00002339645,0.0009317569,0.0009949628,0.00000349396,0.00001187648,0.0001073741,0.000007543802,0.0003970462,0.9962338,0.0000101436,0.001275928,0.000002734721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940112,0.002092349,0.001166568,0.00009527674,0.00004601029,0.00004524788,0.0003472874,0.0001497069,0.002046324],"genre_scores_gemma":[0.9943365,0.00108681,0.001448513,0.00005009913,0.000009986008,0.00003015896,0.0005031253,0.00002095275,0.002513716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001397941,"threshold_uncertainty_score":0.00467658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0171028105132984,"score_gpt":0.2709378620574062,"score_spread":0.2538350515441078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}