{"id":"W3099890097","doi":"10.1053/j.seminhematol.2020.11.006","title":"Genetic and epigenetic modification of human primary NK cells for enhanced antitumor activity","year":2020,"lang":"en","type":"article","venue":"Seminars in Hematology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute","keywords":"Epigenetics; Immunotherapy; Biology; Immune system; Chimeric antigen receptor; Cytotoxic T cell; Immunology; Gene delivery; Cancer research; Cancer immunotherapy; Genetic enhancement; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001497837,0.0001652169,0.0002594747,0.0001056395,0.0001286383,0.0002949293,0.0001576028,0.0001786436,0.004580169],"category_scores_gemma":[0.0001265366,0.0001081224,0.0002044209,0.00007776062,0.0001658964,0.0001055537,0.0001675685,0.0005619006,0.0006070348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000205909,"about_ca_system_score_gemma":0.0002337745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003157495,"about_ca_topic_score_gemma":0.0006618191,"domain_scores_codex":[0.9998804,0.00001700348,0.000009887718,0.0000265046,0.00002598863,0.00004014487],"domain_scores_gemma":[0.9999504,0.00001276781,0.000007356422,0.00001335696,0.000006291261,0.000009790466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002140796,0.00007842168,0.0001719355,0.00001939622,0.000005575876,0.00002689285,0.0000121308,0.0001697711,0.9967239,0.0001203576,0.00006978655,0.002387687],"study_design_scores_gemma":[0.00006223777,0.0005013765,0.001926325,0.000003054771,0.0000232661,0.0001696993,0.00001878917,0.0006883547,0.9944696,0.00004396146,0.002090932,0.000002458368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945155,0.000638461,0.002689826,0.00008563582,0.00006103417,0.00005836348,0.0002610711,0.00008749973,0.001602613],"genre_scores_gemma":[0.9976075,0.0001607049,0.0005879443,0.00002117778,0.000004523111,0.00002235046,0.0001743612,0.00001231318,0.001409126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004580169,"threshold_uncertainty_score":0.01532221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04052090034891256,"score_gpt":0.33916994809734,"score_spread":0.2986490477484274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}