{"id":"W3099890097","doi":"10.1053/j.seminhematol.2020.11.006","title":"Genetic and epigenetic modification of human primary NK cells for enhanced antitumor activity","year":2020,"lang":"en","type":"article","venue":"Seminars in Hematology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute","keywords":"Epigenetics; Immunotherapy; Biology; Immune system; Chimeric antigen receptor; Cytotoxic T cell; Immunology; Gene delivery; Cancer research; Cancer immunotherapy; Genetic enhancement; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000140056,0.0001037487,0.0004490069,0.00009856315,0.00002685654,0.000003223744,0.00008514153,0.0001073985,0.0001118169],"category_scores_gemma":[0.000074415,0.0001068741,0.00004764781,0.000154637,0.0001739049,0.00001948002,0.00004830004,0.0001335366,0.000003330577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003644114,"about_ca_system_score_gemma":0.00006571918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001253496,"about_ca_topic_score_gemma":0.000006146837,"domain_scores_codex":[0.9990336,0.00006109673,0.0002562699,0.0003058174,0.0001216103,0.000221663],"domain_scores_gemma":[0.999358,0.0001863544,0.00008805991,0.0002223916,0.00005608405,0.00008910083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000401398,0.0001142676,0.005677166,0.001065079,0.00001689856,0.000016591,0.000580375,0.000005262191,0.9788455,0.00008699121,0.0001053214,0.01308509],"study_design_scores_gemma":[0.001257343,0.0007177816,0.01649947,0.00008986596,0.00002302865,0.00003722688,0.0000646671,0.0005992728,0.9802263,0.000267219,0.0001334894,0.00008437824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954091,0.001229632,0.0013835,0.0005280143,0.0000329235,0.0008949863,0.000006046416,0.00001531865,0.0005004757],"genre_scores_gemma":[0.9965605,0.0005760824,0.002414599,0.0001177037,0.00003091625,0.00007754404,0.00000870157,0.0000208671,0.0001931483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01300071,"threshold_uncertainty_score":0.4358198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04052090034891256,"score_gpt":0.33916994809734,"score_spread":0.2986490477484274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}