{"id":"W3099933115","doi":"10.3390/biomedicines8110484","title":"Induction of Durable Antitumor Response by a Novel Oncolytic Herpesvirus Expressing Multiple Immunomodulatory Transgenes","year":2020,"lang":"en","type":"article","venue":"Biomedicines","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada)","funders":"","keywords":"Oncolytic virus; Herpes simplex virus; Immune system; Cancer research; Biology; Lytic cycle; Virus; Bystander effect; Tumor microenvironment; Virology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001231051,0.0003036309,0.0002044431,0.0001652814,0.00007007369,0.0002963377,0.0001987051,0.0002387875,0.0002982694],"category_scores_gemma":[0.00007755755,0.0000821823,0.0002102653,0.0001254493,0.0001940728,0.0001905274,0.000227054,0.0004008462,0.0001756558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002961877,"about_ca_system_score_gemma":0.0001681434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000159136,"about_ca_topic_score_gemma":0.0001647367,"domain_scores_codex":[0.999902,0.000008134638,0.000009929851,0.00002490795,0.00002779059,0.00002727317],"domain_scores_gemma":[0.9999361,0.000006016489,0.00002601461,0.00001209164,0.00000601805,0.00001385131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003488587,0.00001665838,0.000124822,0.00001459204,0.00000221442,0.00002569435,0.000005984678,0.0001343622,0.9980651,0.0001161774,0.00001047288,0.001449084],"study_design_scores_gemma":[0.00001350263,0.0004046234,0.0009138914,0.000003906116,0.00001179068,0.0002992471,0.000005638508,0.0007218051,0.9953766,0.00004975655,0.002196061,0.00000315735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892523,0.001230513,0.008325803,0.00006732193,0.00003130264,0.0000361807,0.0001562262,0.0001259192,0.0007744986],"genre_scores_gemma":[0.9913557,0.0006703933,0.006100693,0.00002409396,0.0000117745,0.000027382,0.0003019797,0.00001858567,0.001489276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003036309,"threshold_uncertainty_score":0.002149045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03340259161355595,"score_gpt":0.2951936429863145,"score_spread":0.2617910513727585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}