{"id":"W3099933115","doi":"10.3390/biomedicines8110484","title":"Induction of Durable Antitumor Response by a Novel Oncolytic Herpesvirus Expressing Multiple Immunomodulatory Transgenes","year":2020,"lang":"en","type":"article","venue":"Biomedicines","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada)","funders":"","keywords":"Oncolytic virus; Herpes simplex virus; Immune system; Cancer research; Biology; Lytic cycle; Virus; Bystander effect; Tumor microenvironment; Virology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003352445,0.0001674554,0.0002265953,0.00007886989,0.00007650471,0.00001164717,0.0002249742,0.000125908,0.00003114848],"category_scores_gemma":[0.0001788305,0.0001505355,0.00007893665,0.000261106,0.0002447237,0.000008451429,0.00004425032,0.00008988209,0.000006003848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001801313,"about_ca_system_score_gemma":0.0001727363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004595546,"about_ca_topic_score_gemma":0.000009285209,"domain_scores_codex":[0.998755,0.0001108575,0.0002941769,0.0003475177,0.0002467889,0.0002456269],"domain_scores_gemma":[0.9993402,0.00003268936,0.000101748,0.0002926921,0.0001009101,0.0001317171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009164356,0.0001098377,0.0004456939,0.00005168301,0.00006505141,0.000002799486,0.0002238844,0.00002601887,0.9846749,2.868284e-7,0.002076034,0.003159505],"study_design_scores_gemma":[0.002006418,0.002282489,0.0008920584,0.00003897386,0.00001408983,0.000007816975,0.0002824465,0.0002113824,0.9685012,0.000001119971,0.02560667,0.0001553168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992445,0.004688502,0.001129916,0.001251446,0.0001291422,0.0002447507,0.00006879527,0.00002190564,0.00002052939],"genre_scores_gemma":[0.9986322,0.000194424,0.0002913956,0.0003893833,0.0002430249,0.00002058542,0.00006997168,0.0000350262,0.0001239767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02353064,"threshold_uncertainty_score":0.613866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03340259161355595,"score_gpt":0.2951936429863145,"score_spread":0.2617910513727585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}