{"id":"W3100103606","doi":"10.1089/bioe.2020.0030","title":"Biophysical Investigation of Sodium Channel Interaction with β-Subunit Variants Associated with Arrhythmias","year":2020,"lang":"en","type":"article","venue":"Bioelectricity","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Sodium channel; Protein subunit; Biophysics; Electrophysiology; Nav1.5; Chemistry; Ion channel; Cell biology; Biology; Gene; Sodium; Biochemistry; Neuroscience; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007976355,0.000187392,0.0004386155,0.00009258415,0.00007274817,0.000008042029,0.00004696663,0.0001300343,0.00001988217],"category_scores_gemma":[0.0001561119,0.0001371658,0.0000827791,0.0009903237,0.0001426168,0.0001129371,0.00001623901,0.000380935,0.00001667424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007368468,"about_ca_system_score_gemma":0.0002084833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004133803,"about_ca_topic_score_gemma":0.000006354723,"domain_scores_codex":[0.9988727,0.000100502,0.0002052276,0.0003135079,0.0002397939,0.0002682418],"domain_scores_gemma":[0.9991608,0.00009311584,0.0002095074,0.0001496041,0.0002217752,0.0001652022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01049338,0.0003380956,0.007025771,0.0001577201,0.001109891,0.0004785556,0.001345418,0.0001220722,0.9754752,0.0005365598,0.001194066,0.001723302],"study_design_scores_gemma":[0.005380194,0.01564731,0.1997332,0.000304688,0.0007273663,0.0004217002,0.00009150089,0.01271682,0.7640352,0.0003020291,0.00007076049,0.0005691951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962326,0.00002741878,0.0008409413,0.00201832,0.00003763127,0.0003279255,0.00001005389,0.0001016601,0.0004034786],"genre_scores_gemma":[0.9984994,0.00001244442,0.0001099644,0.0008973238,0.0003068622,0.00001489103,0.00008621506,0.00002332975,0.00004959266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.21144,"threshold_uncertainty_score":0.5593458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02243287171470942,"score_gpt":0.2347614904712107,"score_spread":0.2123286187565012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}