{"id":"W3100178082","doi":"10.1101/2020.11.09.375162","title":"Diverse chemotypes drive biased signaling by cannabinoid receptors","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Endocannabinoid system; Receptor; Cannabinoid receptor; Cannabinoid; Signal transduction; G protein-coupled receptor; Biology; Drug discovery; Computational biology; Neuroscience; Cell biology; Chemistry; Bioinformatics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001573456,0.0003323485,0.0002841696,0.000322494,0.0002001262,0.0002948719,0.0001943274,0.0002553154,0.001937309],"category_scores_gemma":[0.0001889667,0.0001543306,0.0003043999,0.0002447687,0.0001498587,0.0001991324,0.0002532375,0.0003937253,0.0005395254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002983519,"about_ca_system_score_gemma":0.0001963415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005459777,"about_ca_topic_score_gemma":0.0009533223,"domain_scores_codex":[0.999773,0.0000305269,0.00001979349,0.00003993384,0.00007090736,0.0000658522],"domain_scores_gemma":[0.9999197,0.00001957373,0.00001958617,0.000007950774,0.00001681111,0.00001645481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001067353,0.00002074958,0.0002055847,0.0000487928,0.000004925328,0.00004635479,0.000006911347,0.0001789856,0.9978901,0.0001032193,0.00008087195,0.001306928],"study_design_scores_gemma":[0.00002473451,0.0003996225,0.002859739,0.00001552012,0.00001760212,0.0001983268,0.00003562761,0.001266877,0.9924378,0.0001107169,0.002620782,0.00001270722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898556,0.003212728,0.002521977,0.0001864961,0.0000498464,0.00007530423,0.0008268158,0.0000888171,0.003182365],"genre_scores_gemma":[0.9930895,0.001439169,0.002886152,0.0002679365,0.000008613947,0.00005813536,0.0006299443,0.00001812805,0.001602415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001937309,"threshold_uncertainty_score":0.006480932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01905437741959618,"score_gpt":0.2496916852825879,"score_spread":0.2306373078629917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}