{"id":"W3100299358","doi":"10.1093/brain/awaa342","title":"Stage-specific links between plasma neurofilament light and imaging biomarkers of Alzheimer’s disease","year":2020,"lang":"en","type":"article","venue":"Brain","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; HEC Montréal; McGill University","funders":"H2020 European Research Council; National Institutes of Health; Wallenberg Centre for Molecular and Translational Medicine; UK Dementia Research Institute; Vetenskapsrådet; Canada Foundation for Innovation; National Institute on Aging; Alzheimer's Association; Consortium canadien en neurodégénérescence associée au vieillissement; Canadian Institutes of Health Research; Weston Brain Institute; Northern California Institute for Research and Education; AbbVie; University of Southern California; BioClinica; National Institute of Biomedical Imaging and Bioengineering; Torsten Söderbergs Stiftelse; Alzheimer's Disease Neuroimaging Initiative; U.S. Department of Defense","keywords":"Dementia; Pittsburgh compound B; Alzheimer's disease; Neurodegeneration; Alzheimer's Disease Neuroimaging Initiative; Atrophy; Neuroimaging; Medicine; Psychology; Disease; Internal medicine; Amyloid (mycology); White matter; Pathology; Neuroscience; Oncology; Magnetic resonance imaging; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009284803,0.000175968,0.0002861494,0.00007324185,0.00006204266,0.00002429538,0.00007512839,0.00004310661,0.0001387256],"category_scores_gemma":[0.00008299555,0.0001499425,0.000105455,0.000182773,0.0001000812,0.0000802834,0.0001020043,0.0001711353,0.00005036357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001935409,"about_ca_system_score_gemma":0.0001351394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001280638,"about_ca_topic_score_gemma":2.863331e-7,"domain_scores_codex":[0.9986217,0.00007373269,0.0002484709,0.0003718068,0.000382803,0.0003014887],"domain_scores_gemma":[0.9984345,0.0001002776,0.00007144397,0.0002401958,0.00004809051,0.001105425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002410598,0.0005267333,0.894645,0.0003766431,0.009961962,0.002523953,0.0006068757,0.000001787703,0.006993196,0.0002352119,0.03148978,0.05022828],"study_design_scores_gemma":[0.007071729,0.0005981578,0.9465172,0.0001917398,0.001472365,0.000008609478,0.0002937007,0.0009991239,0.01484072,0.00006785207,0.02758064,0.0003581457],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9327042,0.01811964,0.00003763187,0.04674624,0.0000396825,0.0008898278,0.0002376303,0.000088695,0.001136515],"genre_scores_gemma":[0.9985734,0.0001742694,0.0002137576,0.0007320695,0.0001310963,0.0000172042,0.0001035547,0.00003240937,0.00002229988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0658692,"threshold_uncertainty_score":0.6114476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0517555797056066,"score_gpt":0.308978309393119,"score_spread":0.2572227296875124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}