{"id":"W3100299358","doi":"10.1093/brain/awaa342","title":"Stage-specific links between plasma neurofilament light and imaging biomarkers of Alzheimer’s disease","year":2020,"lang":"en","type":"article","venue":"Brain","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; HEC Montréal; McGill University","funders":"H2020 European Research Council; National Institutes of Health; Wallenberg Centre for Molecular and Translational Medicine; UK Dementia Research Institute; Vetenskapsrådet; Canada Foundation for Innovation; National Institute on Aging; Alzheimer's Association; Consortium canadien en neurodégénérescence associée au vieillissement; Canadian Institutes of Health Research; Weston Brain Institute; Northern California Institute for Research and Education; AbbVie; University of Southern California; BioClinica; National Institute of Biomedical Imaging and Bioengineering; Torsten Söderbergs Stiftelse; Alzheimer's Disease Neuroimaging Initiative; U.S. Department of Defense","keywords":"Dementia; Pittsburgh compound B; Alzheimer's disease; Neurodegeneration; Alzheimer's Disease Neuroimaging Initiative; Atrophy; Neuroimaging; Medicine; Psychology; Disease; Internal medicine; Amyloid (mycology); White matter; Pathology; Neuroscience; Oncology; Magnetic resonance imaging; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006661228,0.000229394,0.000253372,0.0006083347,0.0002615399,0.0004080282,0.0002407333,0.0003914896,0.0008397823],"category_scores_gemma":[0.00195682,0.0001974742,0.0002286119,0.000389801,0.0002558995,0.000355209,0.0002980363,0.0004042001,0.0001487566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002331092,"about_ca_system_score_gemma":0.0001578198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002095933,"about_ca_topic_score_gemma":0.002949308,"domain_scores_codex":[0.9997713,0.00004665535,0.00002411457,0.00008555966,0.00003440235,0.00003798461],"domain_scores_gemma":[0.9988255,0.0002304026,0.0005505721,0.0001022953,0.0001770262,0.0001142218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005005785,0.00002152162,0.995314,0.000007788729,0.0000624209,0.00006037712,0.00008405124,0.00003342202,0.002397504,0.00001608549,0.00004717361,0.001455068],"study_design_scores_gemma":[0.000003479969,0.00006114211,0.9993574,0.000001544118,0.00001482184,0.0001330917,0.00003286052,0.00008069166,0.0002122893,0.00002589648,0.00007497505,0.000001780971],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991307,0.000330861,0.000108242,0.00001598083,0.000003595149,0.00000386503,0.0001227698,0.000003580976,0.0002804165],"genre_scores_gemma":[0.9994214,0.00006346797,0.0001332019,0.00001300257,0.000007146489,0.000003967475,0.0001795196,0.00000171967,0.0001765146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002095933,"threshold_uncertainty_score":0.004167497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0517555797056066,"score_gpt":0.308978309393119,"score_spread":0.2572227296875124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}