{"id":"W3100414769","doi":"10.1177/1352458520971819","title":"Siponimod: Disentangling disability and relapses in secondary progressive multiple sclerosis","year":2020,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Novartis Pharma","keywords":"Medicine; Multiple sclerosis; Placebo; Confounding; Marginal structural model; Internal medicine; Physical therapy; Oncology; Pathology; Alternative medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004164717,0.0002811959,0.0003539144,0.00004742857,0.0002900847,0.0001745148,0.0002629858,0.0001735047,0.00005647044],"category_scores_gemma":[0.0009388376,0.0002596208,0.0001726786,0.0001818104,0.0002382062,0.00003887315,0.000238403,0.0004729627,0.00000429523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003352157,"about_ca_system_score_gemma":0.00007261432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003531307,"about_ca_topic_score_gemma":0.00006607172,"domain_scores_codex":[0.9980119,0.0001868839,0.00053868,0.000554604,0.0002453262,0.0004626191],"domain_scores_gemma":[0.9989903,0.00008460489,0.000212017,0.0002291352,0.00008519954,0.0003987347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003393298,0.0001136453,0.4499507,0.00003399092,0.00004351831,0.000008036292,0.0004779036,0.000188457,0.5309703,0.000002832838,0.0001985978,0.01767276],"study_design_scores_gemma":[0.006628017,0.0002721327,0.821902,0.0002477207,0.0000570643,0.00005271951,0.001260291,0.00368265,0.1634027,0.00003104214,0.001854386,0.0006092864],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926106,0.00573962,0.0003368113,0.000668975,0.0002618236,0.0002615975,0.00005482175,0.00002278913,0.00004295813],"genre_scores_gemma":[0.9951245,0.001036185,0.002116362,0.0006050314,0.001009462,0.00002475001,0.0000340711,0.00004360651,0.000006086503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3719513,"threshold_uncertainty_score":0.9999856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05395101021926731,"score_gpt":0.2388006627769648,"score_spread":0.1848496525576975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}