{"id":"W3100414769","doi":"10.1177/1352458520971819","title":"Siponimod: Disentangling disability and relapses in secondary progressive multiple sclerosis","year":2020,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Novartis Pharma","keywords":"Medicine; Multiple sclerosis; Placebo; Confounding; Marginal structural model; Internal medicine; Physical therapy; Oncology; Pathology; Alternative medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01949364,0.0006712436,0.001140722,0.0004124974,0.0002619272,0.0007071724,0.0006182403,0.0006132915,0.003343741],"category_scores_gemma":[0.01401207,0.0002588683,0.002414981,0.0004182748,0.0006217331,0.0006766411,0.0008285883,0.001245892,0.0001705547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004266119,"about_ca_system_score_gemma":0.001152562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005491867,"about_ca_topic_score_gemma":0.0009775818,"domain_scores_codex":[0.99279,0.006240279,0.0001233698,0.0003450614,0.0003930393,0.0001082983],"domain_scores_gemma":[0.9886342,0.008797254,0.001528449,0.0006513651,0.0001091464,0.0002795633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.4138122,0.002538289,0.2032719,0.003009703,0.02408604,0.0005575318,0.0005466585,0.03973702,0.01262331,0.008589484,0.001986257,0.2892417],"study_design_scores_gemma":[0.07857925,0.1204106,0.4360353,0.0006908943,0.0312219,0.001632396,0.0003442812,0.2594164,0.01915481,0.04313254,0.009152031,0.0002296023],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9711613,0.002390389,0.02202936,0.0004744783,0.00003964374,0.0008911586,0.0007408818,0.0001434692,0.002129319],"genre_scores_gemma":[0.9939739,0.0003981776,0.004523152,0.00008916315,0.00002109614,0.000268344,0.0002452414,0.000008793811,0.0004721006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01949364,"threshold_uncertainty_score":0.1030934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05395101021926731,"score_gpt":0.2388006627769648,"score_spread":0.1848496525576975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}