{"id":"W3100507885","doi":"10.1038/s41398-020-01076-x","title":"Disruption of estradiol regulation of orexin neurons: a novel mechanism in excessive ventilatory response to CO2 inhalation in a female rat model of panic disorder","year":2020,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Neuroscience of respiration and sleep","field":"Neuroscience","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec; Hotchkiss Brain Institute; University of Calgary","funders":"Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Ministério da Ciência, Tecnologia e Inovação; Government of Canada","keywords":"Orexin; Endocrinology; Internal medicine; Medicine; Hypothalamus; Excitatory postsynaptic potential; Basal (medicine); Inhibitory postsynaptic potential; Inhalation; Respiratory system; Estrous cycle; Hormone; Anesthesia; Neuropeptide; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002910695,0.0001303205,0.0002331411,0.0003520031,0.00003184995,0.000007846981,0.0001833042,0.00007407318,0.00002166806],"category_scores_gemma":[0.0001887569,0.0001417838,0.00008067649,0.000985752,0.00008623764,0.0003442031,0.00001452237,0.0001321532,0.000001976564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001534136,"about_ca_system_score_gemma":0.0002201382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006484421,"about_ca_topic_score_gemma":0.00004953064,"domain_scores_codex":[0.9981259,0.0001490922,0.0007029772,0.000380257,0.0004988475,0.0001429007],"domain_scores_gemma":[0.9993285,0.0001223998,0.0002754207,0.0001560568,0.00004861387,0.00006903817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001177577,0.0002318243,0.00632897,0.00005608387,7.701522e-7,3.641638e-7,0.001144491,0.1692106,0.8079187,0.01366317,0.000001683202,0.0002657486],"study_design_scores_gemma":[0.003095933,0.000524959,0.2301532,0.0001613548,0.00001350807,0.000003072807,0.0001862664,0.5636185,0.19398,0.007990392,0.00001577412,0.0002569918],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.970502,0.00002195247,0.02656215,0.002128715,0.000138222,0.0005211082,0.00005344722,0.00001366574,0.00005872511],"genre_scores_gemma":[0.9973499,0.00000567387,0.002250855,0.0003300858,0.00001478615,0.00001794495,0.000005501533,0.00001432464,0.00001097333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6139387,"threshold_uncertainty_score":0.5781776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05102583215865016,"score_gpt":0.2934598094275383,"score_spread":0.2424339772688882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}