{"id":"W3100521696","doi":"10.1093/infdis/jiaa683","title":"Clinical Impact of Pretreatment Human Immunodeficiency Virus Drug Resistance in People Initiating Nonnucleoside Reverse Transcriptase Inhibitor–Containing Antiretroviral Therapy: A Systematic Review and Meta-analysis","year":2020,"lang":"en","type":"review","venue":"The Journal of Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Impact","funders":"World Health Organization; ZonMw; Bill and Melinda Gates Foundation","keywords":"Efavirenz; Emtricitabine; Reverse-transcriptase inhibitor; Regimen; Lamivudine; Medicine; Drug resistance; Virology; Nucleoside Reverse Transcriptase Inhibitor; Population; Internal medicine; HIV drug resistance; Reverse transcriptase; Virus; Antiretroviral therapy; Viral load; Biology; Environmental health; Polymerase chain reaction; Microbiology; Hepatitis B virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002033582,0.0006431085,0.0104628,0.0006706588,0.0001504853,0.0000389021,0.0002344196,0.0001005829,0.00009727298],"category_scores_gemma":[0.0005913801,0.000314979,0.005811796,0.001590865,0.0001179915,0.0001603913,0.0000493575,0.0005774676,0.000003073885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004578129,"about_ca_system_score_gemma":0.000786306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001399309,"about_ca_topic_score_gemma":0.0001147069,"domain_scores_codex":[0.9931477,0.002135953,0.00357535,0.0003101648,0.0005539159,0.0002768634],"domain_scores_gemma":[0.9946567,0.0008985015,0.003477885,0.0005061917,0.0002293411,0.0002313628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.000425956,0.002642586,0.01799211,0.5073647,0.4647085,0.0006944265,0.003549833,0.000003881778,0.000003398289,0.00001506267,0.0003830467,0.002216441],"study_design_scores_gemma":[0.001598707,0.001041221,0.0006485973,0.06196476,0.9337693,0.000169165,0.0001445188,0.000001361897,9.371917e-7,0.00001167241,0.0003598218,0.0002898632],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008494456,0.9887918,0.000005687322,0.0001071531,0.00002963162,0.00234369,0.0001416689,0.00001763339,0.00006829558],"genre_scores_gemma":[0.0901397,0.9094042,0.0000401853,0.00009979583,0.00003303666,0.00007514454,0.00003363624,0.00004489896,0.0001294439],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4690608,"threshold_uncertainty_score":0.9999302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05376882230958936,"score_gpt":0.3789094235719955,"score_spread":0.3251406012624062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}