{"id":"W3100521696","doi":"10.1093/infdis/jiaa683","title":"Clinical Impact of Pretreatment Human Immunodeficiency Virus Drug Resistance in People Initiating Nonnucleoside Reverse Transcriptase Inhibitor–Containing Antiretroviral Therapy: A Systematic Review and Meta-analysis","year":2020,"lang":"en","type":"review","venue":"The Journal of Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Impact","funders":"World Health Organization; ZonMw; Bill and Melinda Gates Foundation","keywords":"Efavirenz; Emtricitabine; Reverse-transcriptase inhibitor; Regimen; Lamivudine; Medicine; Drug resistance; Virology; Nucleoside Reverse Transcriptase Inhibitor; Population; Internal medicine; HIV drug resistance; Reverse transcriptase; Virus; Antiretroviral therapy; Viral load; Biology; Environmental health; Polymerase chain reaction; Microbiology; Hepatitis B virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01082749,0.002158019,0.01595669,0.006099961,0.0006478726,0.003288857,0.001893444,0.001877903,0.002926422],"category_scores_gemma":[0.02956037,0.001318483,0.03213247,0.008332141,0.0006042352,0.001509986,0.001372737,0.001432971,0.000285562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002252146,"about_ca_system_score_gemma":0.003703203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008885033,"about_ca_topic_score_gemma":0.01917771,"domain_scores_codex":[0.9919723,0.00321171,0.002667891,0.0009352731,0.0009111207,0.0003016185],"domain_scores_gemma":[0.9794572,0.01503091,0.003147891,0.0005625297,0.001560073,0.0002415085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0009624211,0.00001932292,0.009313918,0.4158438,0.5624141,0.0001776245,0.0001008165,0.0004900632,0.0001901465,0.0001181275,0.0007148816,0.009654694],"study_design_scores_gemma":[0.0002335087,0.0001177276,0.00567642,0.03158103,0.9603095,0.0001285858,0.00005567441,0.000158505,0.00009844381,0.0001377386,0.001479756,0.0000230536],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005385927,0.9928747,0.0003145326,0.0001708229,0.00009708407,0.0001750736,0.0007235188,0.0000171227,0.0002411893],"genre_scores_gemma":[0.2083036,0.7866424,0.001618465,0.0008343611,0.0002049354,0.000774359,0.001259235,0.00002798124,0.0003345776],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01595669,"threshold_uncertainty_score":0.05726194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05376882230958936,"score_gpt":0.3789094235719955,"score_spread":0.3251406012624062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}