{"id":"W3100538981","doi":"10.1136/jitc-2020-sitc2020.0379","title":"379 Initial safety, efficacy, and product attributes from the SURPASS trial with ADP-A2M4CD8, a SPEAR T-cell therapy incorporating an affinity optimized TCR targeting MAGE-A4 and a CD8α co-receptor","year":2020,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"CD8; Medicine; T-cell receptor; Internal medicine; Antigen; Cancer; T cell; Gastroenterology; Oncology; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001627317,0.0005189734,0.000867628,0.00007318844,0.0004846163,0.0003957403,0.000225641,0.0002088382,0.0001500033],"category_scores_gemma":[0.001210124,0.0003587706,0.00009039772,0.0003097787,0.001035082,0.0003364893,0.0001394323,0.0009105758,0.00001066612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000521771,"about_ca_system_score_gemma":0.00066706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005842632,"about_ca_topic_score_gemma":0.00003859822,"domain_scores_codex":[0.9963791,0.0005882738,0.0006779556,0.0009860826,0.0007941758,0.0005744064],"domain_scores_gemma":[0.9971172,0.0005823215,0.0003449008,0.0004838826,0.0002020696,0.001269629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1053972,0.0007482465,0.03675377,0.0003466146,0.0008368751,0.0003951435,0.008434168,0.0001358993,0.8326491,0.00003510619,0.005593158,0.008674676],"study_design_scores_gemma":[0.3172357,0.01546181,0.1096702,0.001072746,0.001013397,0.0004627105,0.005204679,0.002866653,0.5051961,0.0003610411,0.03841686,0.00303809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877034,0.001649774,0.00002821818,0.00748589,0.0001339909,0.002383176,0.0002162904,0.0001462076,0.0002530504],"genre_scores_gemma":[0.9901129,0.0006692586,0.005553754,0.0009491079,0.001863468,0.00004592682,0.000591942,0.0001150676,0.00009858899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.327453,"threshold_uncertainty_score":0.9998865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05083607555745884,"score_gpt":0.2917466332077279,"score_spread":0.240910557650269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}