{"id":"W3100538981","doi":"10.1136/jitc-2020-sitc2020.0379","title":"379 Initial safety, efficacy, and product attributes from the SURPASS trial with ADP-A2M4CD8, a SPEAR T-cell therapy incorporating an affinity optimized TCR targeting MAGE-A4 and a CD8α co-receptor","year":2020,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"CD8; Medicine; T-cell receptor; Internal medicine; Antigen; Cancer; T cell; Gastroenterology; Oncology; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008312513,0.0004039794,0.000607916,0.000178731,0.0002849887,0.0008003062,0.0002456715,0.0005471027,0.009161918],"category_scores_gemma":[0.0006825455,0.0001311445,0.0007176354,0.0002444998,0.0002623519,0.0003737135,0.0002129056,0.00117866,0.001378825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007850422,"about_ca_system_score_gemma":0.0008189744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008434701,"about_ca_topic_score_gemma":0.002052281,"domain_scores_codex":[0.9996426,0.0001158292,0.00003203085,0.00004754466,0.00009497879,0.00006699381],"domain_scores_gemma":[0.999631,0.00008760576,0.00005712142,0.00002791199,0.00003724193,0.0001590084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4685028,0.01875611,0.0239404,0.001103905,0.001187254,0.001002517,0.0002449608,0.006661091,0.1230549,0.001295026,0.02887215,0.3253789],"study_design_scores_gemma":[0.09476595,0.6296777,0.09426986,0.000189366,0.001779164,0.002306387,0.0001643523,0.003501612,0.06646082,0.001591491,0.1051796,0.0001137781],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.965351,0.002518254,0.001050534,0.0006358518,0.0001173315,0.001767789,0.01071345,0.00009511669,0.01775069],"genre_scores_gemma":[0.9671536,0.001438629,0.001287419,0.0009462998,0.0001001809,0.001023818,0.01806052,0.00006218573,0.009927367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009161918,"threshold_uncertainty_score":0.03064966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05083607555745884,"score_gpt":0.2917466332077279,"score_spread":0.240910557650269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}