{"id":"W3100560073","doi":"10.1016/j.celrep.2020.108390","title":"H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; McGill University; McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; Government of Canada; Ministère de l'Économie, de la Science et de l'Innovation - Québec; Compute Canada; Genome Canada; McGill University","keywords":"Methylation; Methyltransferase; Cancer research; DNA methylation; Chemistry; Biology; Biochemistry; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007546963,0.0001305537,0.0001950218,0.0000793374,0.00003568293,0.00001713609,0.00005771019,0.0001409609,0.00001102479],"category_scores_gemma":[0.0009433698,0.0001174817,0.00004368973,0.0002367732,0.0001131119,0.000008793396,0.00004773373,0.0001045169,4.087478e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001577442,"about_ca_system_score_gemma":0.0001246468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001627071,"about_ca_topic_score_gemma":0.000194429,"domain_scores_codex":[0.9985951,0.0001563199,0.0005815878,0.0003728504,0.0001549026,0.0001392433],"domain_scores_gemma":[0.9991706,0.00005940607,0.0003530822,0.0002448878,0.00007272339,0.00009927366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000488383,0.00003894898,0.02374183,0.0000360247,0.00001098135,0.00002475713,0.0005402439,0.000686679,0.9732724,0.00002967765,0.000004749131,0.001564867],"study_design_scores_gemma":[0.0003338609,0.0001035872,0.02232633,0.00002862201,0.00002059907,0.000006838334,0.0001984211,0.0007081137,0.975558,0.0004767544,0.0001141124,0.0001247329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955425,0.001781889,0.001146749,0.0001344889,0.00006879291,0.0003465334,0.000003125088,0.000005922176,0.0009699471],"genre_scores_gemma":[0.9988238,0.0001212346,0.0008601196,0.00004917526,0.00004587897,0.00001445356,0.00004980795,0.00001535023,0.00002022392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003281204,"threshold_uncertainty_score":0.4790766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02378082247296038,"score_gpt":0.2652960528241033,"score_spread":0.2415152303511429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}