{"id":"W3100577837","doi":"10.1182/blood.2020008676","title":"CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":221,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; U.S. Department of Energy; International Development Research Centre; Office of Science; Government of Ontario; Bristol-Myers Squibb","keywords":"Cereblon; Ubiquitin ligase; Cancer research; Cell biology; Integrated stress response; Stem cell; Chemistry; Biology; Myeloid leukemia; Leukemia; Ubiquitin; Immunology; Biochemistry; Translation (biology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001032403,0.0003570164,0.0002782023,0.000244089,0.0001151208,0.0002609471,0.0002292672,0.0002391962,0.0008380628],"category_scores_gemma":[0.00009988754,0.0001095758,0.0001962386,0.0001881482,0.0001754949,0.0001226134,0.0001782079,0.0003877952,0.0002774098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004909692,"about_ca_system_score_gemma":0.0002603991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005930756,"about_ca_topic_score_gemma":0.001631634,"domain_scores_codex":[0.9998873,0.00001194979,0.00001021614,0.00002522107,0.00004861243,0.00001659578],"domain_scores_gemma":[0.9999499,0.000004433906,0.00001625721,0.000004179175,0.000008546691,0.00001670064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002354329,0.00004752998,0.0009683428,0.00007861744,0.00002083421,0.0001015004,0.00001032473,0.0004502725,0.9833192,0.0002940389,0.0003621096,0.01411172],"study_design_scores_gemma":[0.00008284892,0.0005345672,0.004190894,0.000005642856,0.00003370026,0.0009781158,0.00001238882,0.001306304,0.9803526,0.00006950799,0.01242569,0.000007624627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792607,0.006889266,0.006967187,0.0002855918,0.00005298052,0.0001611884,0.0009551508,0.0005591668,0.00486873],"genre_scores_gemma":[0.9891503,0.002738107,0.00414682,0.0001381115,0.00001073388,0.00005643785,0.001318139,0.0000260522,0.002415254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008380628,"threshold_uncertainty_score":0.003562212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009025599242421198,"score_gpt":0.202692558490278,"score_spread":0.1936669592478568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}