{"id":"W3100577837","doi":"10.1182/blood.2020008676","title":"CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":221,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; U.S. Department of Energy; International Development Research Centre; Office of Science; Government of Ontario; Bristol-Myers Squibb","keywords":"Cereblon; Ubiquitin ligase; Cancer research; Cell biology; Integrated stress response; Stem cell; Chemistry; Biology; Myeloid leukemia; Leukemia; Ubiquitin; Immunology; Biochemistry; Translation (biology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007679405,0.0002604328,0.0002173541,0.00003271076,0.00009760963,0.00005547325,0.0002024627,0.0002347342,0.00001332937],"category_scores_gemma":[0.00002231616,0.0002556218,0.00009823206,0.0001115259,0.00008466678,0.00001160361,0.0002069211,0.0001596504,0.00003791845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003125051,"about_ca_system_score_gemma":0.0001952283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001453404,"about_ca_topic_score_gemma":0.000004058605,"domain_scores_codex":[0.9986469,0.00003179415,0.0002690641,0.0005667032,0.0001784676,0.0003071034],"domain_scores_gemma":[0.9992079,0.000006864863,0.0001135502,0.0003079661,0.00006193533,0.0003017469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005470517,0.0001615163,0.0001413364,0.00003401441,0.0001209771,0.00001256041,0.00008354142,0.00001594346,0.9946622,0.00004148277,0.003521529,0.001150251],"study_design_scores_gemma":[0.004799777,0.000317523,0.0001613932,0.00001581875,0.00007467296,0.00002797915,0.00003250409,0.0003619447,0.966111,0.000007885667,0.02778769,0.0003018179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965721,0.0009799611,0.001099522,0.0003013816,0.0001223913,0.0002939113,0.0000911957,0.00005088627,0.0004885895],"genre_scores_gemma":[0.9960488,0.0002804268,0.001117043,0.001218586,0.0004510435,0.00002367941,0.0000808787,0.00004367885,0.0007358363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02855115,"threshold_uncertainty_score":0.9999896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009025599242421198,"score_gpt":0.202692558490278,"score_spread":0.1936669592478568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}