{"id":"W3100699824","doi":"10.1038/s41418-020-00654-2","title":"Neuronal cell life, death, and axonal degeneration as regulated by the BCL-2 family proteins","year":2020,"lang":"en","type":"review","venue":"Cell Death and Differentiation","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research","keywords":"Programmed cell death; Bcl-2 family; Biology; Necroptosis; Cell biology; Apoptosis; Neuroscience; Degeneration (medical); Neurodegeneration; Axon; Disease; Genetics; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001120664,0.0004545494,0.0004994686,0.0000553372,0.0002796853,0.0001618849,0.0001431878,0.0005050825,0.00001704925],"category_scores_gemma":[0.00002291223,0.0003208262,0.000182314,0.00008946297,0.00003900414,0.0000103815,0.0001369357,0.0002181589,0.00001043713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001929213,"about_ca_system_score_gemma":0.0001568921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002127075,"about_ca_topic_score_gemma":0.000004624645,"domain_scores_codex":[0.998197,0.0002037752,0.0004347229,0.0006861787,0.000229874,0.0002484557],"domain_scores_gemma":[0.9991085,0.00002303829,0.0003286285,0.0002735998,0.00006161022,0.0002046416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001206389,0.000268758,0.00008338254,0.005373419,0.0002113548,0.000006315369,0.00008752183,0.00001277598,0.2593993,0.0008273347,0.003914064,0.7296951],"study_design_scores_gemma":[0.0008725368,0.0004488947,0.000568594,0.0002698572,0.0008379528,0.00002990841,0.00001528245,0.0008724473,0.01008483,0.0001802405,0.9851398,0.0006796602],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02876432,0.9662595,0.003030091,0.00004410938,0.0002139577,0.001169126,0.00007734335,0.00002352302,0.0004179923],"genre_scores_gemma":[0.03463491,0.9583398,0.0001347463,0.0001549948,0.0004046959,0.0001125076,0.004283545,0.00006047523,0.001874355],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9812257,"threshold_uncertainty_score":0.9999244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01772676234465135,"score_gpt":0.234767960876034,"score_spread":0.2170411985313827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}