{"id":"W3100728558","doi":"10.1101/gad.343137.120","title":"The core clock transcription factor BMAL1 drives circadian β-cell proliferation during compensatory regeneration of the endocrine pancreas","year":2020,"lang":"en","type":"article","venue":"Genes & Development","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Swiss Life Stiftung für Chancenreichtum und Zukunft; Norges Forskningsråd; Fondation Novartis Consumer Health; Novo Nordisk Fonden; Vontobel-Stiftung; Novo Nordisk; Université de Genève; Hebrew University of Jerusalem; European Foundation for the Study of Diabetes; Olga Mayenfisch Stiftung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Biology; Circadian rhythm; Cell biology; Circadian clock; Endocrinology; Internal medicine; Glucose homeostasis; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008519411,0.000144465,0.0001950382,0.00003250493,0.0003143084,0.00002257488,0.00009117935,0.00004522415,0.00006165019],"category_scores_gemma":[0.00005497777,0.0000892406,0.00007276129,0.0001524767,0.0000530199,0.00005257267,0.00002448367,0.0001007378,0.00002156842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007956892,"about_ca_system_score_gemma":0.0002695301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007684137,"about_ca_topic_score_gemma":0.00001931508,"domain_scores_codex":[0.9988578,0.00005800825,0.0003738783,0.0002036261,0.0003171982,0.0001894722],"domain_scores_gemma":[0.9994127,0.0000328715,0.0001256837,0.0001892757,0.0001195614,0.0001199783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001758604,0.00004976079,0.07297722,0.0001713047,0.00006553245,0.000001788068,0.002886117,0.00004987299,0.9164954,0.0001764367,0.0004016878,0.006548946],"study_design_scores_gemma":[0.0009197739,0.00005854337,0.2704802,0.00004024101,0.0000393391,0.000006007506,0.0002870661,0.0003104461,0.7092209,0.00000857102,0.01853801,0.0000907751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947268,0.001417169,0.000220775,0.002303865,0.0002817094,0.0006177133,0.000004787105,0.00004693898,0.0003802344],"genre_scores_gemma":[0.9973474,0.0002385079,0.0006896101,0.0005577909,0.000188594,0.00006007476,0.00003843981,0.00001564609,0.0008639358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2072745,"threshold_uncertainty_score":0.3639126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02754084501766489,"score_gpt":0.2271696081281602,"score_spread":0.1996287631104953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}