{"id":"W3100902974","doi":"10.1016/j.clml.2020.11.004","title":"BCL2 Expression in First-Line Diffuse Large B-Cell Lymphoma Identifies a Patient Population With Poor Prognosis","year":2020,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; University of British Columbia; BC Cancer Agency","funders":"Genentech; Celgene; MorphoSys; H. Lundbeck A/S; Juno Therapeutics; Incyte; F. Hoffmann-La Roche; Alexion Pharmaceuticals; Janssen Pharmaceuticals; Gilead Sciences; AstraZeneca; Bristol-Myers Squibb; TG Therapeutics; Amgen","keywords":"Diffuse large B-cell lymphoma; International Prognostic Index; Hazard ratio; Medicine; Internal medicine; Lymphoma; Immunohistochemistry; Confidence interval; Oncology; Population; Proportional hazards model; Venetoclax; Multivariate analysis; Pathology; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000325679,0.0006553618,0.001305449,0.0001782297,0.0002495044,0.0001126211,0.000271364,0.0004790846,0.0001099347],"category_scores_gemma":[0.0005345724,0.0004857499,0.0004822587,0.0006897031,0.0001527899,0.000318128,0.0002933982,0.0001867924,0.0002948974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001297905,"about_ca_system_score_gemma":0.0005262872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003300562,"about_ca_topic_score_gemma":0.0002046564,"domain_scores_codex":[0.9949297,0.0002348715,0.001783873,0.001353611,0.0008620505,0.0008359279],"domain_scores_gemma":[0.9971797,0.0005559825,0.000561469,0.000653233,0.0001833933,0.0008662049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003696717,0.01396549,0.7670847,0.0003354931,0.0001583691,0.001802373,0.0008486339,0.0000307138,0.0002580487,0.00004273572,0.003784544,0.2079923],"study_design_scores_gemma":[0.05062668,0.002820469,0.9254639,0.0008270973,0.0003001468,0.0000672026,0.0002315045,0.002444957,0.008721525,0.00005273011,0.007893755,0.0005500168],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938284,0.0007480606,0.00007026304,0.00249314,0.0002754432,0.001602417,0.00006532804,0.000276798,0.0006401586],"genre_scores_gemma":[0.9929968,0.0004262371,0.001030354,0.004017608,0.0004252519,0.0004616728,0.000394146,0.0001131372,0.0001347832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2074422,"threshold_uncertainty_score":0.9997594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02652340087100352,"score_gpt":0.2869746569630959,"score_spread":0.2604512560920924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}