{"id":"W3101044899","doi":"10.1038/s41467-020-19502-5","title":"CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Congenital Ear and Nasal Anomalies","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Medical Research Council; Ligue Contre le Cancer; Agence Nationale de la Recherche; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Fondation ARC pour la Recherche sur le Cancer; Institut Universitaire de France; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Universität Zürich; Campus France; European Commission; National Science Foundation; Cancer Research UK; Université Bretagne Loire","keywords":"Chromatin; Chromatin remodeling; Cell biology; DNA repair; Chromodomain; Biology; DNA damage; ChIA-PET; DNA; Helicase; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000178042,0.0003872911,0.0002772448,0.000309999,0.000241829,0.0007003093,0.0003160486,0.0003789111,0.002702699],"category_scores_gemma":[0.0001701847,0.0002516444,0.0002514734,0.000106325,0.0003602015,0.0003347515,0.0006121548,0.0004007004,0.0008097054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004844931,"about_ca_system_score_gemma":0.0002960051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006334043,"about_ca_topic_score_gemma":0.001122503,"domain_scores_codex":[0.9997361,0.0000217246,0.00001081389,0.00005892297,0.000100968,0.00007144368],"domain_scores_gemma":[0.9998822,0.00001018318,0.0000276798,0.00001229577,0.00001909157,0.0000485121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001512654,0.00001219361,0.001193832,0.00004566653,0.00001090967,0.0001069228,0.00002868652,0.00006278747,0.9918277,0.0008161419,0.0001185695,0.005625386],"study_design_scores_gemma":[0.00002268742,0.0001566609,0.04841289,0.00001268668,0.00002775732,0.0005174789,0.000122316,0.001419136,0.9417031,0.0003359634,0.007257656,0.00001171223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9634215,0.009663521,0.01542139,0.0003500236,0.0001847465,0.00005440393,0.0005939133,0.0003247648,0.00998577],"genre_scores_gemma":[0.9905061,0.001463982,0.001974123,0.00005132956,0.00001735565,0.0000266823,0.0005121473,0.00002652799,0.00542179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002702699,"threshold_uncertainty_score":0.009041488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05751496933373976,"score_gpt":0.3034766913327591,"score_spread":0.2459617219990194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}