{"id":"W3101044899","doi":"10.1038/s41467-020-19502-5","title":"CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Congenital Ear and Nasal Anomalies","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Medical Research Council; Ligue Contre le Cancer; Agence Nationale de la Recherche; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Fondation ARC pour la Recherche sur le Cancer; Institut Universitaire de France; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Universität Zürich; Campus France; European Commission; National Science Foundation; Cancer Research UK; Université Bretagne Loire","keywords":"Chromatin; Chromatin remodeling; Cell biology; DNA repair; Chromodomain; Biology; DNA damage; ChIA-PET; DNA; Helicase; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001113655,0.00007015984,0.0001361327,0.00001937011,0.0001704147,0.00001268675,0.0002203725,0.000106467,0.00001260785],"category_scores_gemma":[0.0001393501,0.00004715353,0.00006635008,0.0001286551,0.0001625304,0.00004045242,0.0001033219,0.0002889913,0.000001740801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007331766,"about_ca_system_score_gemma":0.00003588086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001390707,"about_ca_topic_score_gemma":0.00019867,"domain_scores_codex":[0.9995658,0.00001970762,0.0001602853,0.00009528094,0.00008823015,0.00007067672],"domain_scores_gemma":[0.9988079,0.0003746876,0.00006645158,0.0005583752,0.0001359509,0.00005664485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"observational","study_design_scores_codex":[0.00846449,0.001088333,0.07053345,0.001801281,0.00167541,0.000007059311,0.0257552,0.00001561366,0.2435682,0.3534219,0.02744395,0.2662251],"study_design_scores_gemma":[0.009177227,0.0008572012,0.653979,0.0002274436,0.00121629,0.00003930737,0.001756778,0.007497443,0.03296112,0.002990346,0.2888418,0.0004559947],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7864252,0.03407393,0.0004950861,0.1584108,0.0001314064,0.002118457,0.0003343911,0.0001391806,0.01787152],"genre_scores_gemma":[0.9980357,0.000366646,0.0007709905,0.0004796252,0.00006271968,0.00003001298,0.0001203643,0.000009471592,0.0001244768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5834455,"threshold_uncertainty_score":0.1922865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05751496933373976,"score_gpt":0.3034766913327591,"score_spread":0.2459617219990194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}