{"id":"W3101089668","doi":"10.1056/nejmoa2027187","title":"First-Line Lorlatinib or Crizotinib in Advanced <i>ALK</i> -Positive Lung Cancer","year":2020,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":1064,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Cancer Research UK; Pfizer","keywords":"Crizotinib; Anaplastic lymphoma kinase; ALK inhibitor; Lung cancer; Cancer research; Medicine; Internal medicine; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001018804,0.0002646435,0.0007940938,0.0001867526,0.0001305916,0.0003765257,0.0003536005,0.0002784928,0.001038264],"category_scores_gemma":[0.00173529,0.00008018268,0.0004772625,0.0002222016,0.000149848,0.0002039362,0.0001390607,0.0005628273,0.0001888578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009637053,"about_ca_system_score_gemma":0.0007027813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008659295,"about_ca_topic_score_gemma":0.003178408,"domain_scores_codex":[0.9996531,0.0001773473,0.00003230132,0.0000356338,0.00005494619,0.00004664129],"domain_scores_gemma":[0.9993792,0.0001653637,0.0002281331,0.00002348908,0.00005658658,0.0001471715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1282235,0.002258768,0.1880452,0.005181463,0.003470806,0.001157344,0.0001985201,0.003632524,0.01690597,0.0002608654,0.01400459,0.6366603],"study_design_scores_gemma":[0.05610426,0.10709,0.7509196,0.00146641,0.006887888,0.01163562,0.0002992293,0.008700921,0.02083331,0.0007142682,0.03526773,0.00008083002],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.935586,0.05881425,0.0003457065,0.001167176,0.0001148101,0.0001735841,0.000398617,0.00005663834,0.003343294],"genre_scores_gemma":[0.9917966,0.006895158,0.0002211108,0.0002792512,0.000095442,0.00004843329,0.0003197884,0.000004102328,0.0003401167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001038264,"threshold_uncertainty_score":0.006992161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02574200789427179,"score_gpt":0.3619308581690756,"score_spread":0.3361888502748038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}