{"id":"W3101174158","doi":"10.1016/j.jid.2020.09.020","title":"Research Techniques Made Simple: Preclinical Development of Combination Antitumor Targeted Therapies in Dermatology","year":2020,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Cutaneous Lymphoma Foundation","keywords":"Medicine; Clinical trial; Targeted therapy; Combination therapy; Prioritization; Drug; Malignancy; Drug development; In vivo; Cancer; Pharmacology; Oncology; Internal medicine; Biology; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002370778,0.0008549555,0.000617597,0.0009398184,0.0004919188,0.001181385,0.0006979615,0.0009531838,0.005116869],"category_scores_gemma":[0.001139354,0.000544774,0.0006948141,0.0004221424,0.0009654868,0.001579645,0.000523049,0.00418275,0.001069107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004339985,"about_ca_system_score_gemma":0.0009909015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004782877,"about_ca_topic_score_gemma":0.0008932435,"domain_scores_codex":[0.9990026,0.0003226148,0.00006591904,0.0001406949,0.0003268993,0.0001411657],"domain_scores_gemma":[0.9993221,0.0001867355,0.0001353137,0.0001479235,0.0001069229,0.0001010193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001361493,0.002017035,0.000517634,0.0006765629,0.00009632335,0.0002387653,0.0001485689,0.0009278981,0.914661,0.005378632,0.002283617,0.0716924],"study_design_scores_gemma":[0.0009695277,0.02330708,0.002779829,0.0001813202,0.0003438484,0.001836473,0.0001686845,0.002019093,0.904968,0.003000482,0.06037153,0.00005411922],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.6970686,0.08698193,0.1623704,0.007294787,0.005169644,0.002799531,0.001511758,0.001438486,0.03536499],"genre_scores_gemma":[0.8497722,0.04623209,0.08648696,0.001051134,0.0008689218,0.0009376671,0.0008055565,0.0001830501,0.0136624],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.005116869,"threshold_uncertainty_score":0.01711768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1451068651535191,"score_gpt":0.4251670234765556,"score_spread":0.2800601583230365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}