{"id":"W3101188435","doi":"10.5267/j.ccl.2020.11.001","title":"S-Methylene linkage comprising 1,3,4-oxadiazoles: synthesis, reaction optimization and in vitro anti-microbial potential","year":2020,"lang":"en","type":"article","venue":"Current Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chemistry; Methylene; Broth microdilution; In vitro; Potency; Bacterial strain; Stereochemistry; Linkage (software); Gram; Strain (injury); Combinatorial chemistry; Bacteria; Organic chemistry; Biochemistry; Minimum inhibitory concentration; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001486917,0.0002982867,0.0002049858,0.0001302933,0.00009695227,0.000127874,0.0002461772,0.0001938306,0.00131515],"category_scores_gemma":[0.0001386898,0.00009732465,0.0001387225,0.0002088944,0.0001354672,0.0001851074,0.0001380939,0.0003246413,0.0003215548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001912804,"about_ca_system_score_gemma":0.0002445194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005328943,"about_ca_topic_score_gemma":0.0018209,"domain_scores_codex":[0.9999238,0.00001411724,0.000006919425,0.0000133465,0.0000165104,0.0000252444],"domain_scores_gemma":[0.9999421,0.000007967926,0.00001956715,0.00000635685,0.000009936122,0.00001411085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001486569,0.00007446008,0.0001885961,0.0001684778,0.000004979488,0.0001800494,0.00003830626,0.0003922798,0.9934914,0.0002315954,0.00007445306,0.005006717],"study_design_scores_gemma":[0.00003836869,0.00249418,0.002247483,0.00001530089,0.00002324856,0.0003834511,0.00004662462,0.0006454759,0.9877893,0.00005165179,0.006252749,0.00001218886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892197,0.003260514,0.004252493,0.0001034579,0.00002672971,0.00006017753,0.0002486068,0.00005295269,0.002775355],"genre_scores_gemma":[0.9900912,0.002296237,0.004685267,0.00003995034,0.00001013937,0.00003713691,0.0003050931,0.000006856567,0.002528109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00131515,"threshold_uncertainty_score":0.004399598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01796113235809103,"score_gpt":0.221325703653498,"score_spread":0.2033645712954069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}