{"id":"W3101188435","doi":"10.5267/j.ccl.2020.11.001","title":"S-Methylene linkage comprising 1,3,4-oxadiazoles: synthesis, reaction optimization and in vitro anti-microbial potential","year":2020,"lang":"en","type":"article","venue":"Current Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chemistry; Methylene; Broth microdilution; In vitro; Potency; Bacterial strain; Stereochemistry; Linkage (software); Gram; Strain (injury); Combinatorial chemistry; Bacteria; Organic chemistry; Biochemistry; Minimum inhibitory concentration; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009634511,0.0002433188,0.0003214235,0.00001950107,0.00008259451,0.00007016994,0.0001636528,0.0001678277,0.0001883704],"category_scores_gemma":[0.0001840984,0.000234134,0.00009666709,0.0001105554,0.0001053832,0.0001200704,0.00009333609,0.0004200905,0.000005329124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007995118,"about_ca_system_score_gemma":0.00001517376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008671955,"about_ca_topic_score_gemma":9.65105e-8,"domain_scores_codex":[0.9987071,0.00003395655,0.0003016915,0.0005215434,0.0001480927,0.0002876893],"domain_scores_gemma":[0.9994192,0.0001102943,0.0001568234,0.0001530986,0.0000192833,0.0001412613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009139592,0.0001028108,0.0006490456,0.0002999062,0.00001515421,0.0000115854,0.00003545286,0.0005453515,0.9875277,7.469224e-8,0.00005319569,0.01066836],"study_design_scores_gemma":[0.0003510273,7.9896e-7,0.0004441096,0.0001111774,0.00003159785,0.00001000716,0.00004662404,0.005376634,0.9930305,9.369251e-7,0.0003158996,0.0002806874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959373,0.0002562414,0.001284666,0.002150885,0.00008411044,0.00005285102,0.00004909308,0.00009359224,0.00009127476],"genre_scores_gemma":[0.9983953,0.0002443615,0.0005228625,0.0001311112,0.0005648719,0.00001066928,0.0001114557,0.00001849534,9.320023e-7],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01038767,"threshold_uncertainty_score":0.9547708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01796113235809103,"score_gpt":0.221325703653498,"score_spread":0.2033645712954069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}