{"id":"W3101368019","doi":"10.1002/jcsm.12642","title":"ACVR2B antagonism as a countermeasure to multi‐organ perturbations in metastatic colorectal cancer cachexia","year":2020,"lang":"en","type":"article","venue":"Journal of Cachexia Sarcopenia and Muscle","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute; Melvin and Bren Simon Cancer Center, Indiana University; National Institutes of Health; Lustgarten Foundation; Savoy Foundation; National Heart, Lung, and Blood Institute; V Foundation for Cancer Research; Indiana Clinical and Translational Sciences Institute; American Cancer Society; U.S. Department of Veterans Affairs; Ralph W. and Grace M. Showalter Research Trust Fund; Office of Research and Development","keywords":"Medicine; Cachexia; Internal medicine; Endocrinology; Colorectal cancer; Skeletal muscle; Ejection fraction; ACVR2B; Receptor; Cancer; Heart failure","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001997072,0.0001768376,0.0002882785,0.0000747409,0.0000751031,0.0000581706,0.0002356828,0.00007657936,0.00006418146],"category_scores_gemma":[0.0003621246,0.0001578861,0.0000976466,0.0001548833,0.00005857231,0.00001918915,0.00009157239,0.000182485,0.000008346498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003917567,"about_ca_system_score_gemma":0.0004574224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006468605,"about_ca_topic_score_gemma":0.0001779328,"domain_scores_codex":[0.9988133,0.00009394129,0.0003943377,0.0002438657,0.0002282808,0.0002262935],"domain_scores_gemma":[0.9991498,0.00002576211,0.0001779824,0.0001067924,0.0001864513,0.0003531978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004003792,0.0001275914,0.00645396,0.00003775258,0.0001057848,0.00005727341,0.001745916,0.0003536845,0.9865567,0.000004761004,0.001386411,0.002769774],"study_design_scores_gemma":[0.007119515,0.002091738,0.2345061,0.0002592723,0.0003839512,0.000239271,0.002308504,0.0006574379,0.656691,0.00004258672,0.09479592,0.0009046913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942217,0.003271673,0.0003375289,0.001730596,0.0001189283,0.0002115807,0.00004493488,0.000006044425,0.00005701445],"genre_scores_gemma":[0.996619,0.0001498929,0.001210604,0.001647017,0.0002282155,0.00001656513,0.00001416266,0.00002964557,0.00008492908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3298658,"threshold_uncertainty_score":0.6438409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02375823181113183,"score_gpt":0.2977465326914289,"score_spread":0.2739883008802971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}