{"id":"W3101376013","doi":"10.1101/2020.11.10.376210","title":"A novel membrane protein Hoka regulates septate junction organization and stem cell homeostasis in the <i>Drosophila</i> gut","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Invertebrate Immune Response Mechanisms","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Japan Society for the Promotion of Science","keywords":"Midgut; Septate junctions; Gene knockdown; Cell biology; Biology; Cytoplasm; Stem cell; Membrane protein; Gene; Biochemistry; Intracellular; Botany; Membrane; Gap junction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008906625,0.0006607319,0.0006923284,0.000307408,0.0002980633,0.0002033949,0.0006719595,0.0009701084,0.00005594201],"category_scores_gemma":[0.0001379258,0.000589826,0.0001026094,0.0009927875,0.0001954253,0.0001774564,0.0005666228,0.001252142,0.0002266039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001830738,"about_ca_system_score_gemma":0.0004250035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008855449,"about_ca_topic_score_gemma":0.000003775951,"domain_scores_codex":[0.9968457,0.0006968384,0.0006659254,0.001072355,0.0001459028,0.0005732482],"domain_scores_gemma":[0.9979832,0.0001032099,0.0005158111,0.001018059,0.000322573,0.00005721486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001467687,0.0001646094,0.00009219049,0.0004048012,0.0001257875,0.00003093318,0.0001497461,0.00001799606,0.9979825,0.0007576603,0.0001217087,0.000005321147],"study_design_scores_gemma":[0.001389949,0.0001118212,0.005484727,0.0002506257,0.000140608,5.188035e-7,0.00003968779,0.00006908763,0.9902332,0.000006891145,0.001646547,0.0006262909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909495,0.003377774,0.0009770888,0.001260402,0.0009733656,0.001944813,0.0001758019,0.0003349525,0.000006339694],"genre_scores_gemma":[0.9981011,0.0004075665,0.0005358296,0.0004446225,0.00008685524,0.0002329593,0.000005977298,0.0001523947,0.00003268942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007749232,"threshold_uncertainty_score":0.9996553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01235726772070334,"score_gpt":0.1856237665101403,"score_spread":0.173266498789437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}