{"id":"W3101434916","doi":"10.1111/acel.13278","title":"Increased transcriptome variation and localised DNA methylation changes in oocytes from aged mice revealed by parallel single‐cell analysis","year":2020,"lang":"en","type":"article","venue":"Aging Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Medical Research Council; Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)","keywords":"Biology; Transcriptome; DNA methylation; Variation (astronomy); Methylation; DNA; Genetics; Cell; Cell biology; Molecular biology; Computational biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002129946,0.0001529739,0.0002080173,0.00008003907,0.00004605853,0.0000412227,0.00008856765,0.0001394258,0.00001754044],"category_scores_gemma":[0.00004095779,0.0001671912,0.00005964964,0.0003039986,0.00002156576,0.000007358747,0.00002630057,0.00008001594,0.000001787726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001540427,"about_ca_system_score_gemma":0.00001521866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006244443,"about_ca_topic_score_gemma":0.0003136335,"domain_scores_codex":[0.9988651,0.0002009311,0.0002276021,0.0004228589,0.0001202408,0.0001633064],"domain_scores_gemma":[0.9995417,0.00005195096,0.00012323,0.0001508984,0.00003638236,0.00009586467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000598426,0.00004917619,0.01228207,0.00002379016,0.00005348644,0.000001198745,0.0008686679,0.0004654563,0.9858189,4.14448e-7,0.00004590371,0.0003310519],"study_design_scores_gemma":[0.001213814,0.0001162244,0.04526192,0.00000619152,0.0002347149,4.034426e-8,0.00008198735,0.005163344,0.9468639,0.00005217834,0.000786598,0.0002190362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701755,0.004267417,0.02470303,0.0004539086,0.0000255712,0.0001605465,0.00004741278,0.00001491098,0.0001516843],"genre_scores_gemma":[0.9957485,0.0005009015,0.002065767,0.0004085559,0.00008482786,0.000009569186,0.001112467,0.00001880805,0.00005061488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03895498,"threshold_uncertainty_score":0.6817861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131993598310777,"score_gpt":0.2179593836885003,"score_spread":0.2066394477053926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}