{"id":"W3101543312","doi":"10.1136/jitc-2020-sitc2020.0727","title":"727 Increased serum levels of EBI3 are associated with poor outcome in hepatocellular carcinoma patients and SRF388, a first-in-class IL-27 blocking antibody, inhibits the growth of murine liver tumors","year":2020,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"TIGIT; Cancer research; Antibody; Cytokine; Hepatocellular carcinoma; Proinflammatory cytokine; Tumor microenvironment; Immune system; Biology; Medicine; Molecular biology; Immunology; T cell; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004490028,0.0002957058,0.0007089576,0.0001534892,0.0000619027,0.00002077303,0.0001168745,0.000152354,0.000008611059],"category_scores_gemma":[0.0005365951,0.0002149046,0.0000880442,0.0004963267,0.000389228,0.000125396,0.00006957367,0.0002908743,4.407888e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009805158,"about_ca_system_score_gemma":0.0001990401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001847465,"about_ca_topic_score_gemma":0.0004515692,"domain_scores_codex":[0.9980083,0.0001053103,0.0007361396,0.000377273,0.000445597,0.0003273576],"domain_scores_gemma":[0.9987668,0.0001039265,0.0004898884,0.0001891659,0.0001574946,0.000292661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005361879,0.0001518725,0.9765156,0.0006507864,0.000116771,0.0001840623,0.001219132,0.000004863386,0.02051385,0.000009457616,0.00003624752,0.00006118421],"study_design_scores_gemma":[0.005393146,0.0004242416,0.9297091,0.001244486,0.0001062767,0.00002799491,0.0002481945,0.0006548507,0.06192373,0.0000150192,0.00003358583,0.0002193599],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996295,0.0006061092,8.759733e-7,0.002178949,0.00004208945,0.0006675317,0.0001569838,0.00002039725,0.00003203708],"genre_scores_gemma":[0.9990776,0.00005413226,0.0000428385,0.0007052981,0.00002635399,0.000007497667,0.00002938468,0.00003607431,0.00002087118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04680647,"threshold_uncertainty_score":0.8763558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02249317592307051,"score_gpt":0.2240064407249474,"score_spread":0.2015132648018769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}