{"id":"W3101543312","doi":"10.1136/jitc-2020-sitc2020.0727","title":"727 Increased serum levels of EBI3 are associated with poor outcome in hepatocellular carcinoma patients and SRF388, a first-in-class IL-27 blocking antibody, inhibits the growth of murine liver tumors","year":2020,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"TIGIT; Cancer research; Antibody; Cytokine; Hepatocellular carcinoma; Proinflammatory cytokine; Tumor microenvironment; Immune system; Biology; Medicine; Molecular biology; Immunology; T cell; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001192617,0.0001844636,0.0002323432,0.0003211214,0.0001903683,0.0001887327,0.00008486322,0.0002171635,0.001217569],"category_scores_gemma":[0.0001855715,0.0001098531,0.0001934558,0.0002530997,0.0001332751,0.00009057634,0.0001122357,0.0002840165,0.0002122736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001617594,"about_ca_system_score_gemma":0.0001536494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00106315,"about_ca_topic_score_gemma":0.001395767,"domain_scores_codex":[0.9999509,0.000007913147,0.000004413727,0.00001101995,0.000009385272,0.0000163379],"domain_scores_gemma":[0.9998509,0.00001874844,0.00004742779,0.000008522242,0.00001321487,0.00006114466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006159889,0.0002737996,0.942531,0.00004275343,0.0001346595,0.0007019446,0.00006701785,0.0001291015,0.04290211,0.00004062114,0.000570335,0.006446803],"study_design_scores_gemma":[0.00005093504,0.0005174961,0.9949704,0.000004175686,0.00004421229,0.0009071125,0.0000584702,0.0003288173,0.002636208,0.0000311531,0.00044676,0.000004233241],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991508,0.0001935388,0.00007013154,0.00003021111,0.00000424665,0.000006049492,0.0001742132,0.000008807081,0.0003620917],"genre_scores_gemma":[0.9991953,0.0000659586,0.00006657738,0.00002287105,0.000006502211,0.000009723562,0.0003514038,0.000002096456,0.0002795535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001217569,"threshold_uncertainty_score":0.004073203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02249317592307051,"score_gpt":0.2240064407249474,"score_spread":0.2015132648018769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}