{"id":"W3101563463","doi":"10.1002/acr2.11187","title":"Adverse Effects of Low‐Dose Methotrexate in a Randomized Double‐Blind Placebo‐Controlled Trial: Adjudicated Hematologic and Skin Cancer Outcomes in the Cardiovascular Inflammation Reduction Trial","year":2020,"lang":"en","type":"article","venue":"ACR Open Rheumatology","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Medicine; Internal medicine; Placebo; Adverse effect; Hazard ratio; Randomized controlled trial; Leukopenia; Gastroenterology; Anemia; Neutropenia; Mucositis; Surgery; Confidence interval; Chemotherapy; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003583916,0.001871652,0.004731157,0.0005207843,0.0008133983,0.001811505,0.0008928048,0.002737144,0.00708948],"category_scores_gemma":[0.005880299,0.0007651884,0.00290903,0.0005008507,0.00141886,0.001106627,0.0005577788,0.003209195,0.000818344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008733611,"about_ca_system_score_gemma":0.001191582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009447177,"about_ca_topic_score_gemma":0.001945257,"domain_scores_codex":[0.996455,0.002353241,0.0003150232,0.0004659464,0.0002075992,0.0002031994],"domain_scores_gemma":[0.9974964,0.0007888824,0.0008440895,0.0001970097,0.0002423466,0.0004311813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9905426,0.001282527,0.0003242175,0.001317048,0.001842579,0.00002263482,0.00002640241,0.00007713042,0.0006244414,0.00007134445,0.0004015059,0.003467581],"study_design_scores_gemma":[0.9893713,0.008289051,0.0007353864,0.00006045148,0.0008950426,0.00001236314,0.000008598243,0.0001647931,0.0001000814,0.00009112349,0.0002648139,0.000007027165],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9418454,0.03218028,0.001864989,0.002535782,0.00275635,0.01099277,0.002297992,0.0003060894,0.005220282],"genre_scores_gemma":[0.9727584,0.0060722,0.002553463,0.001709126,0.001219967,0.01107132,0.001090759,0.00003386091,0.003491006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00708948,"threshold_uncertainty_score":0.02371663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03256494471901807,"score_gpt":0.3359666542461022,"score_spread":0.3034017095270841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}