{"id":"W3101566207","doi":"10.1002/pep2.24210","title":"Recent developments in catalytic amide bond formation","year":2020,"lang":"en","type":"article","venue":"Peptide Science","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Peptide bond; Catalysis; Amide; Combinatorial chemistry; Aryl; Organocatalysis; Amine gas treating; Substrate (aquarium); Atom economy; Organic chemistry; Stoichiometry; Enantioselective synthesis; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000159056,0.00005455647,0.00006232138,0.00002625899,0.00004626097,0.00002588968,0.0002017117,0.00002200714,0.00001074827],"category_scores_gemma":[0.0002935907,0.00004870276,0.00002217927,0.0003842578,0.0000777517,0.00001026153,0.0001033391,0.00003219234,0.00002975471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002893486,"about_ca_system_score_gemma":0.00006493914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008926149,"about_ca_topic_score_gemma":0.00002696002,"domain_scores_codex":[0.9993249,0.000005214944,0.0001311806,0.0002256996,0.000152086,0.0001608772],"domain_scores_gemma":[0.9997393,0.000003532002,0.00003429474,0.00009597305,0.00003710708,0.00008977399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005071854,0.000009447011,0.00229404,0.000003984278,0.000001602982,6.852815e-7,0.00007125345,0.00001980713,0.9824146,0.00001059007,0.0004325334,0.0147364],"study_design_scores_gemma":[0.00009124631,0.00001294233,0.00540368,0.000006613898,0.000002483612,0.000001199301,0.000060998,0.0005534382,0.9674463,0.0000175303,0.0263178,0.00008577554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940799,0.0001133845,0.0002465324,0.0009164298,0.00001453766,0.00004539164,0.000001827627,0.00000500506,0.004576954],"genre_scores_gemma":[0.9983605,0.0001549206,0.0007774332,0.0006056799,0.0000269369,0.000004026881,0.00001514442,0.000002737194,0.00005266755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02588527,"threshold_uncertainty_score":0.1986041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01744555353190946,"score_gpt":0.2467686407192221,"score_spread":0.2293230871873126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}