{"id":"W3101566207","doi":"10.1002/pep2.24210","title":"Recent developments in catalytic amide bond formation","year":2020,"lang":"en","type":"article","venue":"Peptide Science","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Peptide bond; Catalysis; Amide; Combinatorial chemistry; Aryl; Organocatalysis; Amine gas treating; Substrate (aquarium); Atom economy; Organic chemistry; Stoichiometry; Enantioselective synthesis; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002316791,0.0009259948,0.0006990663,0.001347336,0.0003770002,0.001176504,0.0008765156,0.001054699,0.003196891],"category_scores_gemma":[0.001536846,0.0006996382,0.0004895661,0.001379377,0.000791076,0.001845936,0.001300119,0.002222842,0.00255538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000720078,"about_ca_system_score_gemma":0.0007271871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004903425,"about_ca_topic_score_gemma":0.0004937709,"domain_scores_codex":[0.9994062,0.0001064391,0.00006367519,0.0001618512,0.0001674329,0.00009444354],"domain_scores_gemma":[0.9993353,0.0002909456,0.000100493,0.0000465794,0.0001665223,0.00006003126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002735215,0.0003900012,0.0006925326,0.02049543,0.0001854912,0.0008430963,0.0004615853,0.00304304,0.06600003,0.06384943,0.01961801,0.8241479],"study_design_scores_gemma":[0.00003258919,0.0005168658,0.0004923861,0.0007701575,0.0001041202,0.00133299,0.00009292797,0.001162068,0.04352114,0.006976687,0.9449434,0.00005463855],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006327332,0.9580716,0.01117527,0.001097647,0.0008509185,0.00004257746,0.00007751362,0.00009745576,0.02225961],"genre_scores_gemma":[0.04916113,0.9358368,0.008194018,0.00100099,0.001058583,0.00007321596,0.0002027069,0.00003308121,0.004439561],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003196891,"threshold_uncertainty_score":0.01225251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01744555353190946,"score_gpt":0.2467686407192221,"score_spread":0.2293230871873126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}