{"id":"W3101613556","doi":"10.1002/eji.202048687","title":"Splenic erythroid progenitors decrease TNF‐α production by macrophages and reduce systemic inflammation in a mouse model of T cell‐induced colitis","year":2020,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Red pulp; Biology; Spleen; Adoptive cell transfer; Immunology; Inflammation; Tumor necrosis factor alpha; Colitis; Inflammatory bowel disease; Arthritis; Bone marrow; Myeloid; T cell; Internal medicine; Medicine; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000493121,0.0001734699,0.0003702968,0.0002136488,0.00006898319,0.00001259251,0.0001762949,0.0001003802,0.00007574711],"category_scores_gemma":[0.0003506082,0.0001635231,0.00008663278,0.0001368699,0.0001286015,0.0002633758,0.00006336196,0.0005386885,0.00005770044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006510187,"about_ca_system_score_gemma":0.00009662088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001352816,"about_ca_topic_score_gemma":9.073743e-7,"domain_scores_codex":[0.9976118,0.001006002,0.000918536,0.0002092781,0.00004668398,0.0002077108],"domain_scores_gemma":[0.9987251,0.00004009463,0.0008315154,0.0001502202,0.0002139457,0.00003912141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001578666,0.00009002641,0.00008634915,0.00006035686,0.0001124123,0.00001129032,0.001526726,0.0001011865,0.9927512,0.00001516598,0.0008854487,0.002781169],"study_design_scores_gemma":[0.00215067,0.001030666,0.0004786581,0.00009032196,0.00004350603,0.0006936055,0.001343013,0.00005442774,0.9929873,0.00000383281,0.0009904143,0.0001335952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940975,0.003814078,0.0001860587,0.0004887256,0.0009374739,0.0002217672,0.000005742022,0.00002165663,0.0002270538],"genre_scores_gemma":[0.9979439,0.0009211498,0.00009011905,0.00005163898,0.0000619432,0.000003103028,0.00001964047,0.00002846802,0.0008800213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003846472,"threshold_uncertainty_score":0.6668279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01488751313986482,"score_gpt":0.2101160222846895,"score_spread":0.1952285091448246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}