{"id":"W3101633024","doi":"10.2215/cjn.10140620","title":"Effects of Canagliflozin in Patients with Baseline eGFR <30 ml/min per 1.73 m2","year":2020,"lang":"en","type":"article","venue":"Clinical Journal of the American Society of Nephrology","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital; University of British Columbia","funders":"Janssen Pharmaceuticals; Janssen Research and Development; University of Chicago; Relypsa; Bristol-Myers Squibb; Akebia Therapeutics; Mitsubishi Tanabe Pharma Corporation; Novo Nordisk; Eisai; University of Chicago Medicine; Pfizer; Innovent Biologics; AstraZeneca; Amarin Corporation; Regeneron Pharmaceuticals; Ironwood Pharmaceuticals, Incorporated; Alnylam Pharmaceuticals; Daiichi Sankyo Europe; Gilead Sciences; Kowa Company; Sanofi; GlaxoSmithKline; Amgen; Celgene; Eli Lilly and Company","keywords":"Canagliflozin; Medicine; Renal function; Hazard ratio; Internal medicine; Confidence interval; Population; Empagliflozin; Urology; Diabetes mellitus; Creatinine; Placebo; Albuminuria; Type 2 diabetes; Gastroenterology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005232642,0.0001494408,0.001063618,0.00003512458,0.000018552,0.000002308583,0.0002635052,0.00006344324,0.00004121403],"category_scores_gemma":[0.0002291295,0.00008800309,0.0005451873,0.0002836176,0.000852757,0.00003704082,0.0001217292,0.0003820717,0.000003821525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005041144,"about_ca_system_score_gemma":0.0001309353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005049118,"about_ca_topic_score_gemma":0.00000713752,"domain_scores_codex":[0.9981007,0.0002958044,0.0008679417,0.0001725778,0.0003377035,0.0002253001],"domain_scores_gemma":[0.9975213,0.0006986556,0.001200257,0.0002113819,0.0001942326,0.0001741644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003091933,0.002090635,0.8799501,0.0002169152,0.001917639,0.00002469941,0.0005091355,0.00004962344,0.001392733,0.0000140119,0.0870999,0.02364267],"study_design_scores_gemma":[0.009477574,0.01071637,0.9574683,0.0001332105,0.0008981897,0.0000021522,0.0002227852,0.0001648043,0.0001957491,0.00002285522,0.02060631,0.00009167188],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810991,0.0001684786,0.0001304125,0.01814356,0.00008455883,0.0003174783,0.000003997884,0.000004778959,0.00004759854],"genre_scores_gemma":[0.9500703,0.0002550495,0.003565866,0.04587702,0.0001711032,0.000002420582,0.000002313044,0.00001751539,0.00003842106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07751824,"threshold_uncertainty_score":0.3588662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01464695768332685,"score_gpt":0.2888342332748628,"score_spread":0.2741872755915359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}