{"id":"W3101633024","doi":"10.2215/cjn.10140620","title":"Effects of Canagliflozin in Patients with Baseline eGFR <30 ml/min per 1.73 m2","year":2020,"lang":"en","type":"article","venue":"Clinical Journal of the American Society of Nephrology","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital; University of British Columbia","funders":"Janssen Pharmaceuticals; Janssen Research and Development; University of Chicago; Relypsa; Bristol-Myers Squibb; Akebia Therapeutics; Mitsubishi Tanabe Pharma Corporation; Novo Nordisk; Eisai; University of Chicago Medicine; Pfizer; Innovent Biologics; AstraZeneca; Amarin Corporation; Regeneron Pharmaceuticals; Ironwood Pharmaceuticals, Incorporated; Alnylam Pharmaceuticals; Daiichi Sankyo Europe; Gilead Sciences; Kowa Company; Sanofi; GlaxoSmithKline; Amgen; Celgene; Eli Lilly and Company","keywords":"Canagliflozin; Medicine; Renal function; Hazard ratio; Internal medicine; Confidence interval; Population; Empagliflozin; Urology; Diabetes mellitus; Creatinine; Placebo; Albuminuria; Type 2 diabetes; Gastroenterology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001529519,0.0003101238,0.001197795,0.0002922397,0.0001440379,0.0004872207,0.0002362326,0.0004599462,0.002207764],"category_scores_gemma":[0.004318348,0.0001571982,0.001871813,0.0002401182,0.0002085311,0.0004061052,0.0002443202,0.0009244182,0.0001563901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004360261,"about_ca_system_score_gemma":0.0004406787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001131308,"about_ca_topic_score_gemma":0.001635614,"domain_scores_codex":[0.9994528,0.000312741,0.00003464612,0.000066208,0.00006043399,0.00007322242],"domain_scores_gemma":[0.9980374,0.0009818625,0.0004841389,0.0001644909,0.00007389156,0.0002582163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6730811,0.01247947,0.08438443,0.0008992181,0.003268088,0.0002376469,0.0001570989,0.005840327,0.004555026,0.0004886687,0.003131852,0.2114771],"study_design_scores_gemma":[0.1408325,0.2868259,0.5231002,0.0003882715,0.006793082,0.0004613699,0.0001996953,0.02611924,0.005737252,0.001946091,0.007498149,0.00009832214],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914916,0.004779752,0.0005160448,0.0005585504,0.0001270119,0.0001161221,0.0003141639,0.00005512411,0.002041636],"genre_scores_gemma":[0.9977096,0.0006613713,0.0005548167,0.0003378344,0.00009006524,0.00006217493,0.0002198825,0.000003886711,0.0003603146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002207764,"threshold_uncertainty_score":0.008088946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01464695768332685,"score_gpt":0.2888342332748628,"score_spread":0.2741872755915359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}