{"id":"W3101637373","doi":"10.1038/s41467-020-19473-7","title":"Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Qatar National Research Fund; Genentech; National Institutes of Health; U.S. National Library of Medicine; IXICO; H. Lundbeck A/S; National Cancer Institute; Servier; Dementia Australia; Eisai; Australian Government; F. Hoffmann-La Roche; University of Southern California; Pfizer; BioClinica; Biogen; Dementia Collaborative Research Centres, Australia; Edith Cowan University; Eli Lilly and Company; Bristol-Myers Squibb; Foundation for the National Institutes of Health; Fonds National de la Recherche Luxembourg; Medical Research Council; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; State Government of Victoria; Novartis Pharmaceuticals Corporation; Science and Industry Endowment Fund; Alzheimer's Association; National Institute on Aging; Commonwealth Scientific and Industrial Research Organisation","keywords":"Lipidome; Lipidomics; Sphingolipid; Lipid metabolism; Disease; Computational biology; Monoacylglycerol lipase; Metabolomics; Biology; Bioinformatics; Medicine; Biochemistry; Internal medicine; Endocannabinoid system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001973895,0.0004335187,0.0006518942,0.001170567,0.0006881948,0.001039172,0.000405913,0.0006439921,0.001061233],"category_scores_gemma":[0.00475748,0.000317365,0.0002536971,0.0009811765,0.0005557964,0.0003411692,0.001411384,0.0004815953,0.0002065542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002565584,"about_ca_system_score_gemma":0.000215271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001989836,"about_ca_topic_score_gemma":0.003880536,"domain_scores_codex":[0.9985725,0.0005542253,0.0001365983,0.0004678715,0.0001751301,0.00009360593],"domain_scores_gemma":[0.997754,0.0006202697,0.0005377406,0.000394806,0.000357608,0.0003355104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002938383,0.0001146211,0.9800522,0.00004371259,0.0003276772,0.0005863286,0.0006349702,0.0001212495,0.01086134,0.00009325235,0.0003122632,0.003914016],"study_design_scores_gemma":[0.00005012586,0.0001524547,0.9972619,0.000007618549,0.00009975746,0.0007934271,0.000202644,0.0003576005,0.0006357197,0.0001174467,0.0003114468,0.000009866452],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992944,0.0001352839,0.0002020475,0.00001913183,0.000003505784,0.000009716099,0.0001796163,0.000003750423,0.0001525684],"genre_scores_gemma":[0.9990461,0.00004339548,0.0002688364,0.00002765246,0.000008967811,0.00001725944,0.000486265,0.000005207743,0.00009630913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001989836,"threshold_uncertainty_score":0.0104391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06863085207625412,"score_gpt":0.418306264146427,"score_spread":0.3496754120701729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}