{"id":"W3101652941","doi":"10.3390/cancers12113449","title":"Nimotuzumab Site-Specifically Labeled with 89Zr and 225Ac Using SpyTag/SpyCatcher for PET Imaging and Alpha Particle Radioimmunotherapy of Epidermal Growth Factor Receptor Positive Cancers","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal University Hospital; Canadian Nuclear Laboratories; University of Saskatchewan","funders":"","keywords":"Nimotuzumab; Chemistry; Conjugate; In vivo; Cancer research; Pharmacology; Epidermal growth factor receptor; Medicine; Biochemistry; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008869141,0.0001937379,0.0004272093,0.00003737241,0.0001117266,0.00002470466,0.00006146367,0.00003372809,0.000145964],"category_scores_gemma":[0.00004696218,0.0001506585,0.00006298364,0.0001661903,0.0003718099,0.0001166014,0.00003093902,0.0001648174,0.000001498016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004068658,"about_ca_system_score_gemma":0.0005308673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001662899,"about_ca_topic_score_gemma":0.00003757562,"domain_scores_codex":[0.9987577,0.00004221765,0.000241054,0.0003566844,0.0002321729,0.0003702298],"domain_scores_gemma":[0.9991621,0.0001562647,0.00009677359,0.0001013074,0.0001927229,0.0002908152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01438486,0.00003149838,0.1364165,0.0006205986,0.0005284267,0.00007598063,0.006059221,0.0001037087,0.8304569,0.0002585023,0.00132433,0.009739515],"study_design_scores_gemma":[0.03602258,0.008772041,0.1841533,0.001682086,0.0006596814,0.0004171232,0.006967222,0.1389017,0.5934448,0.0001306038,0.0267857,0.002063194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899287,0.003493603,0.0004140426,0.005218273,0.00004662213,0.0005597578,0.000238356,0.00002096981,0.00007965056],"genre_scores_gemma":[0.9941786,0.001039723,0.002994245,0.001350707,0.0002013787,0.00002306738,0.0000245869,0.00003915459,0.0001485448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2370121,"threshold_uncertainty_score":0.6143677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03758535626944055,"score_gpt":0.3062962255770368,"score_spread":0.2687108693075963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}