{"id":"W3101652941","doi":"10.3390/cancers12113449","title":"Nimotuzumab Site-Specifically Labeled with 89Zr and 225Ac Using SpyTag/SpyCatcher for PET Imaging and Alpha Particle Radioimmunotherapy of Epidermal Growth Factor Receptor Positive Cancers","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal University Hospital; Canadian Nuclear Laboratories; University of Saskatchewan","funders":"","keywords":"Nimotuzumab; Chemistry; Conjugate; In vivo; Cancer research; Pharmacology; Epidermal growth factor receptor; Medicine; Biochemistry; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000157843,0.0003098965,0.0003170955,0.0001299436,0.00009248858,0.0001608001,0.000213944,0.0002387542,0.0006426852],"category_scores_gemma":[0.00008382776,0.0001204256,0.0002078879,0.0001594816,0.0001214447,0.0001338211,0.0001899151,0.0002527575,0.0003514977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003197174,"about_ca_system_score_gemma":0.0001691772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004926285,"about_ca_topic_score_gemma":0.0008013854,"domain_scores_codex":[0.9998519,0.0000283388,0.00001000124,0.00004543248,0.00004126942,0.00002299891],"domain_scores_gemma":[0.9999696,0.000003630486,0.00001035198,0.000004078565,0.000005235978,0.000007062819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003580716,0.000009659017,0.00005916741,0.0000151577,0.000003436509,0.00002763123,0.000005433089,0.00008165072,0.9988489,0.00004806516,0.00002113856,0.0008438221],"study_design_scores_gemma":[0.000007019683,0.0001143125,0.0005260071,0.000001325499,0.000006527097,0.000139414,0.000003017459,0.0006586746,0.9971301,0.000007930673,0.001403167,0.000002508137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893402,0.0008034082,0.007775472,0.00004637063,0.00001795674,0.00007312656,0.0001313154,0.00007850349,0.001733559],"genre_scores_gemma":[0.9795857,0.0006799457,0.015442,0.0000713726,0.00001371146,0.00006835421,0.0003947749,0.00003764183,0.003706406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006426852,"threshold_uncertainty_score":0.002319753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03758535626944055,"score_gpt":0.3062962255770368,"score_spread":0.2687108693075963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}